problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl20156134-8problendo-7715Research ArticleСтатьиArticlesНовые иммунологические методы диагностики аутоиммунного полиэндокринного синдрома 1-го типа (первый опыт в России)The new immunological methods for diagnostics of type 1 autoimmune polyendocrine syndrome (the first experience in Russia)СозаеваЛ СSozaevaL Sleila.sozaeva@gmail.comКармановМ ЕKarmanovM E-БрейвикЛBreivikL-ХусбиЭHusbiE-КареваМ АKarevaM A-ФГБУ «Эндокринологический научный центр»Endocrinology Research CentreФГБУ «Российская детская клиническая больница»Russian Children’s Clinical HospitalУниверситет БергенаUniversity of Bergen201515062015613ТОМ 61, №3 (2015)48Copyright © Созаева Л.С., Карманов М.Е., Брейвик Л., Хусби Э., Карева М.А., 20152015Созаева Л.С., Карманов М.Е., Брейвик Л., Хусби Э., Карева М.А.Sozaeva L.S., Karmanov M.E., Breivik L., Husbi E., Kareva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/7715

Оценивали роль аутоантител (АТ) к интерферонам (ИФН)-ω и -α2 в диагностике аутоиммунного полигландулярного синдрома 1-го типа (АПС 1), а также специфичность и чувствительность метода HEK-Blue cell» для определения этих АТ. В исследование были включены 34 пациента с АПС 1 и 21 пациент с очаговой алопецией. Среди пациентов с АПС 1 высокие титры антител к ИФН-ω обнаружены в 100%, а АТ к ИФН-α2 - в 97% случаев. У всех пациентов с очаговой алопецией соответствующие АТ отсутствовали. Таким образом, определение АТ к ИФН-ω и -α2 с использованием клеток HEK-Blue является высокоспецифичным и высокочувствительным методом диагностики АПС 1.

This study was designed to ascertain the role of anti-interferon (IFN)-ω and -α2 antibodies (AB) in diagnostics of type 1 autoimmune polyglandular syndrome (APS-1) and evaluate specificity and sensitivity of the HEK-Blue cells method used to detect these antibodies. The study included 34 patients presenting with APS-1 and 21 patients with focal alopecia. All 100% of the patients with APS-1 ehxhibited high titers of anti IFN-ω antibodies; 97% of them had anti IFN-a2 antibodies. These antibodies were not found in the patients with focal alopecia. It is concluded that the measurement of anti IFN-α and α2 antibodies with the use of HEK-Blue cells is a highly specific and sensitive method for diagnostics of APS-1.

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The authors declare that there are no conflicts of interest present.