problendoПроблемы ЭндокринологииProblems of Endocrinology0375-96602308-1430Endocrinology Research Centre10.14341/probl9426problendo-9426Research ArticleОригинальные исследованияOriginal StudiesАссоциация аллелей гена адипонектина с сахарным диабетом 2-го типа у жителей БашкортостанаAssociation of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostanhttps://orcid.org/0000-0002-1590-6433АвзалетдиноваДиана ШамилевнаAvzaletdinovaDiana S.

к.м.н.

MD, PhD

hyppocrat@mail.ruhttps://orcid.org/0000-0003-4866-0983ШариповаЛейсан ФаритовнаSharipovaLiaisan F.

аспирант кафедры эндокринологии

graduate student of the department of endocrinology

ecolab_203@mail.ruhttps://orcid.org/0000-0003-2071-0969КочетоваОльга ВладимировнаKochetovaOlga V.

к.б.н.

PhD

olga_mk78@mail.ruhttps://orcid.org/0000-0001-7405-486XМоруговаТатьяна ВячеславовнаMorugovaTatiana V.

д.м.н., проф.

MD, PhD, Professor

tmorugova@yandex.ruhttps://orcid.org/0000-0002-5118-6533МустафинаОльга ЕвгеньевнаMustafinaOlga E.

д.б.н., проф.

PhD, Professor

anmareg@mail.ru<p>ФГБОУ ВО &laquo;Башкирский государственный медицинский университет&raquo; Минздрава России</p>Россия<p>Bashkir State Medical University</p>Russian Federation<p>Институт биохимии и генетики &mdash; обособленное структурное подразделение ФГБНУ &laquo;Уфимский федеральный исследовательский центр&raquo; Российской академии наук</p>Россия<p>Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences</p>Russian Federation2019140520196513138Copyright &#x00A9; Авзалетдинова Д.Ш., Шарипова Л.Ф., Кочетова О.В., Моругова Т.В., Мустафина О.Е., 20192019Авзалетдинова Д.Ш., Шарипова Л.Ф., Кочетова О.В., Моругова Т.В., Мустафина О.Е.Avzaletdinova D.S., Sharipova L.F., Kochetova O.V., Morugova T.V., Mustafina O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.probl-endojournals.ru/jour/article/view/9426

Сахарный диабет 2-го типа (СД2) является одной из острейших проблем современного мира. Заболевание характеризуется высокой частотой микро- и макрососудистых осложнений. СД2 — многофакторное полигенное заболевание, структура наследственной предрасположенности к которому может иметь популяционно-специфические особенности.

Цель исследования — анализ ассоциаций аллелей гена адипонектина ADIPOQ (rs17366743) с СД2, его клинико-метаболическими характеристиками и осложнениями у жителей Республики Башкортостан.

Материал и методы

Материал и методы. Генотипирование по полиморфному маркеру rs17366743 гена адипонектина ADIPOQ 433 пациентов с СД2 и 428 здоровых жителей Башкортостана проведено с использованием метода полимеразной цепной реакции (ПЦР) синтеза ДНК.

Результаты

Результаты. В группе пациентов с СД2 выявлена более высокая частота генотипа CT и аллеля С, чем в контрольной группе (15,7% против 6,8%; p=0,0002 и 7,8% против 3,4%; p<0,0001 соответственно). Среди пациентов с СД2 генотип ТТ и аллель Т выявлены с меньшей частотой, чем среди здоровых лиц (84,3 и 93,2%; p=0,0002; 92,2 и 96,6%; p<0,0001 соответственно). Показана ассоциация изученных генотипов и аллелей с развитием диабетической ретинопатии и катаракты (p=0,044 и p=0,008 соответственно).

Заключение

Заключение. Аллель С и генотип СТ являются маркерами риска развития СД2 (OR=2,43 и 2,56 соответственно).

Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific.

Aim — the analysis of allelic associations of adiponectin gene (ADIPOQ, rs17366743) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan.

Material and methods

Material and methods. 3 PCR-based method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan.

Results

Results. The ratio of genotype CT and allele С was higher in T2DM patients compared with controls (15.7% vs. 6.8%; p=0.0002 and 7.8% vs. 3.4%; p<0.0001, respectively). Genotype ТТ and allele Т were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; p=0.0002; 92.2 and 96.6%, p<0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown (p=0,044, p=0,008, respectively).

Conclusions

Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).

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The authors declare that there are no conflicts of interest present.