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Роль лептина и ядерного рецептора PPARγ в патогенезе синдрома поликистоза яичников

https://doi.org/10.14341/probl12620

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Аннотация

Синдром поликистоза яичников (СПКЯ) является наиболее распространенной причиной эндокринного бесплодия у женщин. Одним из основных патогенетических звеньев данного заболевания является инсулинорезистентность. При этом механизмы развития СПКЯ при инсулинорезистентности окончательно не установлены. Лептин и рецептор, активируемый пролифераторами пероксисом гамма (Peroxisome Proliferator-Activated Receptor γ; PPARγ), участвуют в регуляции углеводного обмена и репродуктивной функции, что указывает на возможность их вовлечения в патогенез СПКЯ. Статья представляет собой обзор публикаций по данной проблеме. Целью обзора явилась систематизация имеющихся сведений о молекулярных механизмах, определяющих роль лептина и PPARγ в развитии СПКЯ. Литературный поиск проводился в период с 05.04.2020 по 17.05.2020 с использованием баз научной литературы: NCBI PubMed (зарубежные источники) и «Киберленинка» (отечественные источники), анализировались литературные источники за период 1990–2020 гг.
В обзоре отражены современные представления о роли лептина и PPARγ в регуляции эндокринной, иммунной систем и репродуктивной функции, а также в развитии СПКЯ. Показано, что в настоящее время отсутствуют работы, освещающие механизмы взаимодействия лептина и PPARγ в патогенезе данного синдрома. Имеющиеся публикации, указывающие на индивидуальный вклад в развитие заболевания и ассоциации лептина и PPARγ с СПКЯ, представляют противоречивые результаты и обладают большим количеством ограничений. Это определяет актуальность дополнительного, более детального изучения прямого и непрямого взаимодействия лептина и PPARγ в реализации физиологических процессов, а также в патогенезе СПКЯ.

Об авторах

К. Д. Иевлева
Научный центр проблем здоровья семьи и репродукции человека
Россия

Иевлева Ксения Дмитриевна.
664003, ул. Тимирязева, д. 16, Иркутск.
eLibrary SPIN: 2743-9932



И. Н. Данусевич
Научный центр проблем здоровья семьи и репродукции человека
Россия

Данусевич Ирина Николаевна - доктор медицинских наук.
664003, ул. Тимирязева, д. 16, Иркутск.
eLibrary SPIN: 6289-3358



Л. В. Сутурина
Научный центр проблем здоровья семьи и репродукции человека
Россия

Сутурина Лариса Викторовна - профессор, доктор медицинских наук.
664003, ул. Тимирязева, д. 16, Иркутск.
eLibrary SPIN: 9419-0244



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Иевлева К.Д., Данусевич И.Н., Сутурина Л.В. Роль лептина и ядерного рецептора PPARγ в патогенезе синдрома поликистоза яичников. Проблемы Эндокринологии. 2020;66(6):74-80. https://doi.org/10.14341/probl12620

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Ievleva K.D., Danusevich I.N., Suturina L.V. Role of leptin and nuclear receptor PPARγ in PCOS pathogenesis. Problems of Endocrinology. 2020;66(6):74-80. (In Russ.) https://doi.org/10.14341/probl12620

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