Antithyroid antibodies and autoimmune diseases of the thyroid
https://doi.org/10.14341/probl10392
Abstract
The significance and mechanisms of action of different antithyroid antibodies in diffuse toxic goiter (Graves' disease) and chronic lymphocytic thyroiditis (Hashimoto’s disease) arc analyzed. Antibodies immediately decreasing the level of cAMP in isolated thyrocytes were revealed in the sera of adolescents with juvenile struma, often resulting from lymphocytic thyroiditis. Complement-fixing cytotoxic antibodies are heterogeneous in patients with Graves' diseases and Hashimoto's thyroiditis. Thyrocytes from the tissue of diffuse toxic goiter are resistant to the cytolytic effect of such antibodies from patients with Graves' diseases but not from patients with Hashimoto's thyroiditis. The causes and mechanisms of development of resistance of thyrocytes from diffuse toxic goiter to antibody-dependent complement-mediated cytotoxicity of sera from patients with Graves' disease and the possibility of using this phenomenon as a differential diagnostic test are discussed.
About the Authors
V. I. KandrorEndocrinology Research Center
Russian Federation
I. V. Kryukova
Endocrinology Research Center
Russian Federation
S. I. Krainova
Endocrinology Research Center
Russian Federation
N. A. Mkrtumova
Endocrinology Research Center
Russian Federation
Yu. M. Keda
Endocrinology Research Center
Russian Federation
N. Yu. Sviridenko
Endocrinology Research Center
Russian Federation
E. N. Bazarova
Endocrinology Research Center
Russian Federation
N. V. Latkina
Endocrinology Research Center
Russian Federation
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Review
For citations:
Kandror V.I., Kryukova I.V., Krainova S.I., Mkrtumova N.A., Keda Yu.M., Sviridenko N.Yu., Bazarova E.N., Latkina N.V. Antithyroid antibodies and autoimmune diseases of the thyroid. Problems of Endocrinology. 1997;43(3):25-30. (In Russ.) https://doi.org/10.14341/probl10392
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