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Проблемы Эндокринологии

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Анализ некоторых компонентов механизма стимуляции катехоламинами трансэпителиального транспорта натрия

https://doi.org/10.14341/probl197622497-100

Аннотация

A study was made of the influence of adrenaline of certain components-of the transepithelial sodium transport system in the frog skin and on energy sources-providing its activating effect. Adrenaline proved to increase the sodium transport through the frog skin decreasing its electrical resistance. Strophanthin К prevented the reaction of frog skin to adrenaline completely. Monoiodacetate also produced an inhibitory action on the adrenaline effect which was eliminated on addition of pyruvate into the solution. Potassium cyanide and 2,4-dinitrophenol considerably weakened the adrenaline stimulation of transepithelial sodium transport. A conclusion was drawn that an increase of sodium transport by the frog skin in the action of catecholamines was associated with increase of its ionic permeability and the activation of the ionic pump. It is supposed that the principal source of energy provision for the stimulating effect of catecholamines, were processes of aerobic energy metabolism.

Об авторах

О Б Кузьмин
Оренбургский государственный медицинский университет


А А Лебедев



Список литературы

1. Waltington С. O.//Am. J. Physiol. 1968, v. 214, p. 1001-1004.

2. Fassina G., Carpenedo F., Fiandini G.//J. Pharmac. Pharmacol. 1968, v. 20, p. 240-242.

3. Кузьмин О. Б. Влияние кахелоламинов на транспорт натрия в коже лягушки//Фармакол. и токсикол. 1975. Т. 38, № 1. с. 64-66.

4. Кузьмин О. Б. Проб. эндокринол. 1975. № 2. с. 58-62.

5. Forte J. G., Davies R. E.//Am. J. Physiol. 1963. v. 204. p. 812-816.

6. Koefoed-Johnsen V., Ussing H. H.//Arbi physiol, scand. 1958, v. 42, p. 298-308.

7. Наточин Ю. В.//Биофизика. 1966. №4. с. 626-630.

8. Леонтьев В. Г., Наточии Ю. В.//Докл. АН СССР. 1965, т. 165, с. 962-965.

9. Himms-Hagen J.//Heffter A. Handbuch der experirnentellen Pharmakologle. Bd 33. Berlin. 1972. S. 363-462.


Рецензия

Для цитирования:


Кузьмин О.Б., Лебедев А.А. Анализ некоторых компонентов механизма стимуляции катехоламинами трансэпителиального транспорта натрия. Проблемы Эндокринологии. 1976;22(4):97-100. https://doi.org/10.14341/probl197622497-100

For citation:


Kuzmin O.B., Lebedev A.A. ANALYSIS OF CERTAIN COMPONFNTS IN THE MECHANISM OF CATECHOLAMINE STIMULATION OF TRANSEPITHELIAL SODIUM TRANSPORT. Problems of Endocrinology. 1976;22(4):97-100. https://doi.org/10.14341/probl197622497-100

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