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Проблемы Эндокринологии

Расширенный поиск

The decreased intensity of EPR cytochrome P-450, adrenodoxine and free radical signal in the dog adrenal cortex under the effect of o,p'-dichlorodiphenyl dichloroethane

https://doi.org/10.14341/probl198329562-65

Аннотация

A study was made of the action of the adrenocorticolytic drug chloditane (o.p'-DDD) on the content of cytochrome P-450, adrenodoxine and free radicals in the dog adrenal cortex. After a single feeding of 50 mg/kg bw o.p'-DDD EPR signals with ξ-factors 2.25, 1.94 and 2.00 reduced 30-40%. Three-fold feeding of the drug in a dose of 100 mg/kg bw produced a further demonstrable decrease of signals. These changes attest to a possible inhibition of the hydroxylase complex in the adrenal cortex induced by o.p'-DDD.

Рецензия

Для цитирования:

Mikosha A.S., Beregovskaya N.N. The decreased intensity of EPR cytochrome P-450, adrenodoxine and free radical signal in the dog adrenal cortex under the effect of o,p'-dichlorodiphenyl dichloroethane. Проблемы Эндокринологии. 1983;29(5):62-65. https://doi.org/10.14341/probl198329562-65

For citation:

Mikosha A.S., Beregovskaya N.N. The decreased intensity of EPR cytochrome P-450, adrenodoxine and free radical signal in the dog adrenal cortex under the effect of o,p'-dichlorodiphenyl dichloroethane. Problems of Endocrinology. 1983;29(5):62-65. https://doi.org/10.14341/probl198329562-65

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

117292, Российская Федерация, Москва, ул. Дм. Ульянова, д.11

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