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Problems of Endocrinology

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Effect of blood serum hormones and lipoproteins on levels of cAMP and cGMP in viable sections of rat liver

https://doi.org/10.14341/probl198531369-73

Abstract

Cyclic nucleotides are universal intermediary agents of hormones in the target tissues, however mechanisms of the regulation of the cAMP and cGMP content in the cell are rather complex and still obscure. More data have appeared of late on the involvement of blood serum lipoproteins in the regulation of various intracellular processes including adenylate cyclase activity. Therefore the purpose of the study was to investigate the effect of adrenaline, hydrocortisone, glucagon, insulin and blood serum lipoproteins on the cAMP and cGMP content in rat liver surviving sections. An attempt was made to study a cooperative effect of the above hormones and lipoproteins of various classes. The results obtained have shown that adrenaline and glucagon raise the cAMP level in rat liver surviving sections. The effect of adrenaline is mediated by beta-adrenoreceptors. Insulin lowers an increases the level of cAMP in liver sections determined by the effect of glucagon. A decrease of the initial cAMP content in response to insulin occurs after a short lag period. High density lipoproteins (HDLP3) reduce the cAMP content in liver surviving sections. A cooperative effect of lipoproteins of a very low density and adrenaline (or hydrocortisone) in the regulation of the cAMP content in the rat liver was revealed. The cGMP content in rat liver surviving sections does not change under the influence of the above hormones and lipoproteins.

About the Authors

L E Panin
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences


I E Kolosova
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences


References

1. Панин Л. Е. НЕКОТОРЫЕ БИОХИМИЧЕСКИЕ АСПЕКТЫ ПРОБЛЕМЫ АДАПТАЦИИ//В КН.: Медико-биологические аспекты процессов адаптации. Новосибирск, 1975, с. 34-46.

2. Панин Л. Е. О механизме нарушения углеводно-жирового обмена в условиях стресса//В кн.: Современные проблемы биохимии дыхания и клиника. Иваново, 1970, с. 52-56.

3. Панин Л. Е., Третьякова Т. А., Русских Г. С.К механизму действия адаптивных гормонов на ключевые ферменты гликолиза, гликогенолиза и пентозофосфатного пути//В кн.: Механизмы адаптации гомеостатических систем при действии на организм субэкстремальных и экстремальных факторов. Новосибирск, 1980, с. 18-33.

4. Панин Л. Е. Энергетические аспекты адаптации. Л., 1978.

5. Baulieu Е. Е.//Molec. Cell. Endocrinol., 1978, v. 12, p. 247-254.

6. Carrison J. C., Borland M. K//J. biol. Chem.,1979, v. 254, p. 1129-1133.

7. Ghiselli G., Sirtori C. R., Nicosia S.//Biochem. J., 1981, v. 196, p. 899-902.

8. Exton J. H.//Amer. J. Physiol., 1980, v. 238, p. E3-El2.

9. Exton J. H//Biochem. Pharmacol., 1979, v. 28, p. 2237-2240.

10. Hepp К. D., Renner R., Haring H.U.//Hormone Cell Regulat., 1978, v. 2, p. 119-126.

11. Kneer N. M., Bosch A. L., Clark M. G. et a!.//Proc. nat. Acad. Sci. USA, 1974, v 71, p. 4523-4527

12. Pointer R. H., Buther F. R., Fain J. N.//J. biol. Chem., 1976, v. 251, p. 2987-2992.

13. Tolone G., Bonasera L, Sajeva R.//Brit. J. exp. Path., 1979, v. 60, p. 269-275.


Review

For citations:

Panin L.E., Kolosova I.E. Effect of blood serum hormones and lipoproteins on levels of cAMP and cGMP in viable sections of rat liver. Problems of Endocrinology. 1985;31(3):69-73. https://doi.org/10.14341/probl198531369-73

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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