EFFECT OF PREDNISOLONE, GLUCOSE AND INSULIN ADMINISTRATION IN EARLY POSTNATAL ONTOGENESIS ON INDICES OF CARBOHYDRATE-FAT METABOLISM IN ADULT RATS

Abstract

To clear out the role of early postnatal exposures in the formation of glycemic homeostasis in adult rats receiving pharmacological doses of glucocorticoids, glucose (G) or insulin (I) in the early postnatal period (starting from the 2d-8th day) indices of their carbohydrate-fat metabolism were studied. The results of these exposures were assessed by the content of 11-oxycortikosteroids, immunoreactive insulin (IRI), glucose (G), urea and free fat acids (FFA), in the blood; by the glucose tolerance test and the animals' resistance to the diabetogenic affect of alloxan. It was shown that in all the experimental series the IRI level in the blood of the adult animals was lowered. The administration of G or glucocorticoids in the early postnatal period resulted in a decrease in the G concentration and an elevation of the FFA level in the blood, time-legged recovery of the G level in the blood up to the initial values in the glucose tolerance test in the adult animals. Glycemic load in the 1st week of the life of newborn rats increased adult animals' tolerance to the diabetogenic effect of alloxan.