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Проблемы Эндокринологии

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О кооперативном эффекте гидрокортизона, адреналина и липопротеидов высокой плотности в регуляции активности глюкозо-6-фосфатдегидрогеназы в печени

https://doi.org/10.14341/probl198632469-71

Аннотация

The role of adaptive hormones and serum lipoproteins in the regulation of glucose-6-phosphate dehydrogenase (G-6-PDH) activity was investigated. The test was performed on experimental hepatic sections of Wistar rats. It was shown that timely regulation of G-6-PDH by epinephrine and hydrocortisone which inhibits the activity of enzyme is manifested through the cAMP-dependent mechanism. The cooperative effect of epinephrine, hydrocortisone and high-density lipoproteins that enables G-6-PDH activation was revealed. It was stated that only high-density lipoproteins of subpopulation III were capable of hormonal mediating. The effect was caused by the induction of enzyme synthesis and manifested through lysosome-dependent activation of chromatin.

Об авторах

Л Е Панин
Научно-исследовательский институт экспериментальной и клинической медицины;Научно-исследовательский институт биохимии СО РАМН


Т Г Филатова
Научно-исследовательский институт экспериментальной и клинической медицины


Рецензия

Для цитирования:


Панин Л.Е., Филатова Т.Г. О кооперативном эффекте гидрокортизона, адреналина и липопротеидов высокой плотности в регуляции активности глюкозо-6-фосфатдегидрогеназы в печени. Проблемы Эндокринологии. 1986;32(4):69-71. https://doi.org/10.14341/probl198632469-71

For citation:


Panin L.E., Filatova T.G. Cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating the glucose-6-phosphate dehydrogenase activity of the liver. Problems of Endocrinology. 1986;32(4):69-71. https://doi.org/10.14341/probl198632469-71

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)