Cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating the glucose-6-phosphate dehydrogenase activity of the liver
https://doi.org/10.14341/probl198632469-71
Abstract
The role of adaptive hormones and serum lipoproteins in the regulation of glucose-6-phosphate dehydrogenase (G-6-PDH) activity was investigated. The test was performed on experimental hepatic sections of Wistar rats. It was shown that timely regulation of G-6-PDH by epinephrine and hydrocortisone which inhibits the activity of enzyme is manifested through the cAMP-dependent mechanism. The cooperative effect of epinephrine, hydrocortisone and high-density lipoproteins that enables G-6-PDH activation was revealed. It was stated that only high-density lipoproteins of subpopulation III were capable of hormonal mediating. The effect was caused by the induction of enzyme synthesis and manifested through lysosome-dependent activation of chromatin.
About the Authors
L E Panin
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences;Scientific Research Institute of Biochemistry of Siberian Branch of Russian Academy of Medical Sciences
T G Filatova
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences
Review
For citations:
Panin L.E., Filatova T.G. Cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating the glucose-6-phosphate dehydrogenase activity of the liver. Problems of Endocrinology. 1986;32(4):69-71. https://doi.org/10.14341/probl198632469-71
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