INDIVIDUAL POLYMORPHISM OF THE RESPONSE OF THE HYPOPHYSEOGONADAL SYSTEM TO PROLONGER ADMINISTRATION OF A LH-RH ANALOG

Abstract

The paper is concerden with the results of experiments on male Papio hamadryas aimed at the investigation of their hypo,-physeal and gonadal endocrine function by intravenous drip with the help of subcutaneously implanted osmotic mini-pumps of buzerelin, a superactive LH-RH analog. A 2-phase response of the hypophyseogonadal system was revealed. The stimulation of the secretion of LH and testicular androgens in the first 5-7 days of ouzerelin administration was followed by sharp suppression of gonadotropic function of the pituitary gland and testosterone, production. Individual differences in the sensitivity of animals to the drug were noted in parallel with the general regularities of hormonal functional changes of the hypophyseogonadal system in response to prolonged administration of the LH-RH agonist. Individual polymorphism of the body response to the LH-RH agonist was determined by the initial individual differences in the type of functioning of the hypothalamo-hypophyseogonadal system.