FUNCTION OF THE HYPOPHYSEOGONADAL SYSTEM OF PAPYO HAMADRYAD DURING TONIC INFUSION OF BUZERELINE (LH-RH AGONIST)

N D Goncharova; N P Goncharov

doi:10.14341/probl198935568-72

FUNCTION OF THE HYPOPHYSEOGONADAL SYSTEM OF PAPYO HAMADRYAD DURING TONIC INFUSION OF BUZERELINE (LH-RH AGONIST)

N D Goncharova, N P Goncharov

https://doi.org/10.14341/probl198935568-72

Abstract

The authors presented the results of a study of hormonal function of the hypophy-seogonadal system in papyo hamadryad males subjected to continuous infusion of buzereline (LH-RH agonist) at a daily dose of 3 μg/kg of body mass for 4-6 weeks with the help of subcutaneously implanted osmotic mini-pumps. A two-phasic response of the system to the drug was established. Activation of the secretion of hypophyseal gonadotrophins and testicular androgens in the first days of buzereline infusion was followed by sharp inhibition of endocrine function of the hypophyseogonadal system. Functional tests with the administration of LH-RH (100 μg) and human chorionic gonadotrophin (1500 U) to experimental animals demonstrated the leading role of the development of adenohypophyseal desensitization in the mechanism of antifertile drug action.

About the Authors

N D Goncharova

НИИ института экспериментальной патологии и терапии АМН СССР, Сухуми

N P Goncharov

НИИ института экспериментальной патологии и терапии АМН СССР, Сухуми

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Review

For citations:

Goncharova N.D., Goncharov N.P. FUNCTION OF THE HYPOPHYSEOGONADAL SYSTEM OF PAPYO HAMADRYAD DURING TONIC INFUSION OF BUZERELINE (LH-RH AGONIST). Problems of Endocrinology. 1989;35(5):68-72. https://doi.org/10.14341/probl198935568-72

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).

ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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Problems of Endocrinology

FUNCTION OF THE HYPOPHYSEOGONADAL SYSTEM OF PAPYO HAMADRYAD DURING TONIC INFUSION OF BUZERELINE (LH-RH AGONIST)

Abstract

About the Authors

References

Review

For citations:

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