The role of glycosylated metabolic products in the formation of vascular complications of diabetes
https://doi.org/10.14341/probl199743143-46
Abstract
Primary glycosylation undergoes not only albumin, but also other plasma proteins. Glycosylation of apolipoproteins, which are part of low density lipoproteins (LDL), leads to an increase in electrophoretic mobility and a slowdown in the degradation of the latter using fibroblasts, which can contribute to the development of atherosclerosis [51]. Glycosylated LDL are actively subjected to secondary oxidation, as a result of which they acquire atherogenic properties [32].
Significant changes were found in the exchange of very low density glycosylated lipoproteins [35]. The triglycerides contained in them are less likely to be cleaved by lipoprotein lipase. This is one of the factors in maintaining hypertriglyceridemia in diabetes.
About the Authors
N. I. VerbovayaSamara State Medical University
Russian Federation
E. A. Lebedeva
Samara State Medical University
Russian Federation
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Review
For citations:
Verbovaya N.I., Lebedeva E.A. The role of glycosylated metabolic products in the formation of vascular complications of diabetes. Problems of Endocrinology. 1997;43(1):43-46. (In Russ.) https://doi.org/10.14341/probl199743143-46
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