Current views of the effects of thyroid hormones and thyroid-stimulating hormone on bone tissue
https://doi.org/10.14341/probl200652248-54
Abstract
The relationship between thyroid pathology and bone tissue was first noticed as early as 1891, when Recklinghausen described multiple fractures in a patient with untreated thyrotoxicosis. Despite the fact that in the modern etiological and pathogenetic classification of osteoporosis, thyrotoxicosis is included in the group of secondary osteoporosis, various aspects of the action of thyroid hormones on bone tissue continue to be studied to this day.
The purpose of this review is to discuss the mechanisms of the influence of thyroid hormones on bone and, to a greater extent, to analyze new information on the biological and clinical significance of TSH for bone tissue. The review also provides information on the physiology of bone remodeling and the mechanisms of activation of receptors for thyroid hormones and TSH, which is necessary for a more complete understanding of hypotheses that explain the possible ways TSH affects bone cells.
About the Authors
Zh. Ye. BelayaEndocrinology Research Centre
Russian Federation
L. Ya. Rozhinskaya
Endocrinology Research Centre
Russian Federation
G. A. Melnichenko
Endocrinology Research Centre
Russian Federation
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Review
For citations:
Belaya Zh.Ye., Rozhinskaya L.Ya., Melnichenko G.A. Current views of the effects of thyroid hormones and thyroid-stimulating hormone on bone tissue. Problems of Endocrinology. 2006;52(2):48-54. (In Russ.) https://doi.org/10.14341/probl200652248-54
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