Comparative evaluation of the inotropic effect of lipophilic and hydrophilic forms of 17P-estradiol and progesterone
https://doi.org/10.14341/probl199743643-45
Abstract
Changes in the contractility under the effect of lipophilic and hydrophilic 17^-estradiol and progesterone were studied on an isolated atrial auricula. The hydrophilic forms of female sex steroids possessed a higher cardiotropic activity than their lipophilic analogs. Lipophilic 17^-estradiol suppressed, whereas the hydrophilic form boosted the contractile function of the isolated rat atrium. Progesterone depressed cardiac contractility, no matter which forms were used.
About the Authors
A. I. MatyushinRussian State Medical University
Russian Federation
A. N. Karachentsev
Russian State Medical University
Russian Federation
S. A. Isaev
Russian State Medical University
Russian Federation
A. Zh. Mambetova
Russian State Medical University
Russian Federation
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Review
For citations:
Matyushin A.I., Karachentsev A.N., Isaev S.A., Mambetova A.Zh. Comparative evaluation of the inotropic effect of lipophilic and hydrophilic forms of 17P-estradiol and progesterone. Problems of Endocrinology. 1997;43(6):43-45. (In Russ.) https://doi.org/10.14341/probl199743643-45
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