Immune characteristics of patients with insulin-dependent diabetes mellitus with various duration of the disease

The paper presents data on the cellular and humoral immunity in different periods of insulindependent diabetes mellitus (with the disease standing of 0.5±0.4 years, group A; 3±1.8 years, group B; and 15±4 years, group C). Group A patients presented with the immunity system activation: increased counts of T cells, В lymphocytes, T helpers and T inductors, increased share of active T cells (that is, DR positive ones), elevated content of IgM, IgG, IgA (214±51 mg%, 1200±124 mg%, 250±34 mg%, respectively) as against the reference group (156±74, 914±387, 189±49 mg%, respectively) (p<0.01). In group В patients, who suffered a longer disease, the immunity parameters were within the normal range, and in group C patients, in whom the disease standing was the longest, these shifts were contrarywise as against those in group A, that is, T and В cell counts were lowered, as were the counts of T-helpers-inductors, lg levels, and the phagocytosis index was 65±5 vs. 85±10 % in the controls (p<0.05), the phagocytosis level being 4±2 vs. 10±2 in the controls (p<0.05). The authors analyze the association of the HLA system characteristics with the immunity shifts. Patients with the HLA A9, B8, B15, B18, DR3, DR4 presented with significant shifts in the immunity status as against those with the HLA Al, A10, B5, B12, B16, B27, DR5, DR7. These data confirm a high informative value of the HLA markers for predicting the degree of alterations in the immunological homeostasis.

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