Isotopic composition of blood plasma carbon in patients with endocrine diseases
https://doi.org/10.14341/probl11906
Abstract
Forty-eight patients suffering from diabetes mellitus, obesity, hyper- and hypothyrosis, Icenko-Cushing’s disease were examined to elucidate the relationship between blood plasma carbon isotopic composition and the type of the endocrine disease. This value varied within the range of 19.7 to 24.7 ‰, the mean value being 5 ‰. Blood plasma carbon in the diabetics is enriched for 12C light isotope (delta-13C from 23.0 to 24.5 ‰) as against a similar characteristic in obese patients (delta-13C from 20.5 to 21.99 ‰). Patients with hypo- and hyperthyrosis and the Icenko- Cushing’s disease have a wider range of delta-13C values that seems to be explained by the Icenko-Cushing’s disease heterogeneity and the presence of biorhythms. Clear-cut isotopic differences in the blood sera of adults and children were revealed whatever the disease type, these differences indicating the changes in cellular metabolism energy in the ontogenesis. These data can be satisfactorily explained within the frames of the model of cellular division of carbon isotopes, suggested previously.
About the Authors
A. A. IvlevEndocrinology research centre of RAMS
Russian Federation
N. P. Goncharov
Endocrinology research centre of RAMS
Russian Federation
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Review
For citations:
Ivlev A.A., Goncharov N.P. Isotopic composition of blood plasma carbon in patients with endocrine diseases. Problems of Endocrinology. 1993;39(1):36-40. (In Russ.) https://doi.org/10.14341/probl11906
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