Effect of long-acting gestagen levonorgestrel butanate on the spermatogenesis and endocrine function of the adrenals and gonads of papio hamadrias
https://doi.org/10.14341/probl11922
Abstract
Tlie efficacy of levonorgestrel butanate in doses 1, 2, 4, and 8 mg/kg in spermatogenesis suppression was studied in adult male Papio hamadrias. The drug was injected intramuscularly twice with 3 month interval. All gestagen doses had an inhibitory effect of spermatogenesis, this effect increasing with the dosage build-up. None of the animals developed azoospermia, which was due to incomplete suppression of the pituitary gonadotropic function and of testosterone secretion. Hormonal concentration in the peripheral blood was 55-60% reduced in response to the minimal dose and 60-80% reduced in response to the maximal dose. Injection of long-acting gestagen did not influence the secretion of adrenocortical hormones hydrocortisone, dehydroepiandrosterone, and pregnenolone.
About the Authors
N. P. GoncharovEndocrinology research centre; Primatology Center
Russian Federation
G. V. Katsiya
Endocrinology research centre; Primatology Center
Russian Federation
V. Yu. Butnev
Endocrinology research centre; Primatology Center
Russian Federation
V. M. Gorlushkin
Endocrinology research centre; Primatology Center
Russian Federation
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Review
For citations:
Goncharov N.P., Katsiya G.V., Butnev V.Yu., Gorlushkin V.M. Effect of long-acting gestagen levonorgestrel butanate on the spermatogenesis and endocrine function of the adrenals and gonads of papio hamadrias. Problems of Endocrinology. 1996;42(1):37-40. (In Russ.) https://doi.org/10.14341/probl11922
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