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A second KIGS communication on side effects of growth hormone therapy

https://doi.org/10.14341/probl12000

Abstract

By March 25, 1992, among the 16,604 patients included in the KIGS database who had been treated with growth hormone (GH) for at least one year, 135 had serious side effects (SE). Among the most frequent SE are relapses of craniopharyngioma (17) and other brain tumors (11). Changes in bone tissue, joints and muscles were more rarely observed. 7 patients had convulsive syndrome. More information is needed to assess the effect of GH therapy on these complications.

About the Authors

P. J. Chatlein
Endocrinology Research Centre, RAMS
Russian Federation


P. Wilton
Endocrinology Research Centre, RAMS
Russian Federation


References

1. Ranke М. Adverse Events (АЕ) reported during growth hormone therapy. Results of the Kabi International Growth Study (KIGS). Biannual Report.- 1991.- N 6.

2. Arslanian S. A., Becker D. J., Lee P. A. et al. // Amer. J. Dis. Child.- 1985 -Vol. 139.- P. 347-350.

3. Clayton P. E., Shaler S. M., Gattemaneni H. R., Price D. A. // Lancet.- 1987,-Vol. 1.- P. 711-713.

4. Rodens K., Kaplan S. L., Grumbach M. M., Teller U7. N. // Acta endocr. (Kbh.).- 1987 - Vol. 114, Suppl. 283.- P. 188-189.

5. Butenandt O. // Europ. J. Pediat.- 1979.- Vol. 130.- P. 15-28.

6. Judson J., Wyk V., Casella S. J. et al. // Human Growth Hormone / Ed. L. E. Underwood.- New York; Basel, 1988.- P. 25-62.

7. Chatelain P., Penhoat A., Perrard-Sapori M. H. et al. // Acta paediat. scand.- 1988.- Suppl. 347.- P. 104-109.

8. Frasier D. S. // Growth Abnormalities / Eds R. L. Hintz, R. G. Rosenfield.- New York, 1987.- P. 41-58.

9. Daughaday W. H. // Textbook of Endocrinology / Ed. E. R. H. William.- Philadelphia, 1974.- P. 68-74.


Review

For citations:


Chatlein P.J., Wilton P. A second KIGS communication on side effects of growth hormone therapy. Problems of Endocrinology. 1993;39(5):85-88. (In Russ.) https://doi.org/10.14341/probl12000

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