Adrenal steroids in the blood and urine and the immune status of women with age-associated disorders of glucose tolerance
https://doi.org/10.14341/probl12066
Abstract
Dehydroepiandrosterone (DHA), hydrocortisone, and insulin are naturally occurring substances influencing the immune functions. The present paper is devoted to their combined effects on the mitogen-stimulated proliferation of lymphocytes (MSPL) with phytohemagglutinin-M (PHA-M) and Pokeweed mitogen used as stimulants. A positive correlation between blood insulin and urinary DHA levels (r=0.534; p<0.05) has been revealed. The level of DHA secretion was in a negative correlation with the values of MSPL stimulated by PHA-M (r=-0.651; p<0.01). Hence, age-associated hyperinsulinemia may be regarded as an important regulator of both, adrenal androgen production and the cellular immunity status.
About the Authors
V. I. Odin
N. N. Petrov Research Institute of Oncology
Russian Federation
Russian Federation
T. E. Poroshina
N. N. Petrov Research Institute of Oncology
Russian Federation
Russian Federation
E. V. Tsyrlina
N. N. Petrov Research Institute of Oncology
Russian Federation
Russian Federation
L. M. Berstein
N. N. Petrov Research Institute of Oncology
Russian Federation
Russian Federation
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Review
For citations:
Odin V.I., Poroshina T.E., Tsyrlina E.V., Berstein L.M. Adrenal steroids in the blood and urine and the immune status of women with age-associated disorders of glucose tolerance. Problems of Endocrinology. 1996;42(4):14-17. (In Russ.) https://doi.org/10.14341/probl12066
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