Telomere pathology in ontogenesis in patients with Turner syndrome
R. K. Mikheev,
O. R. Grigoryan,
M. S. Pankratova,
E. N. Andreeva,
E. V. Sheremetyeva,
Yu. S. Absatarova,
N. G. Mokrysheva https://doi.org/10.14341/probl12869
Abstract
According to present medical databases there many trials to provide in vivo researches in vivo to confirm/refute shortening process of telomeres among patients with Turner syndrome. Despite the successful clinical experience of providing such patients with Turner syndrome, a lot of omics (proteomic and metabolomic) aspects still stay unclear. Main disadvantages of most researches are small volume and minimized mathematical correlation with chronic disease (coronary heart disease, essential hypertension, cardiovascular malformations). Finally, organization of international prospective multi-centered researches in vivo including patients with mosaic cariotype and co-operation between physicians and biologists are optimal solutions for this present problem.
About the Authors
R. K. Mikheev
Endocrinology research centre
Robert K. Mikheev, resident
11 Dm. Ulyanov str., 117036, Moscow
SPIN-код: 9767-8468
O. R. Grigoryan
Endocrinology research centre
Оlga R. Grigoryan, MD, PhD, Dsc
Moscow
SPIN-код: 3060-8242
M. S. Pankratova
Endocrinology research centre
Maria S. Pankratova, MD, PhD
Moscow
SPIN-код: 3770-4452
E. N. Andreeva
Endocrinology research centre;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Elena N. Andreeva, MD, PhD, Dsc
Moscow
SPIN-код: 1239-2937
E. V. Sheremetyeva
Endocrinology research centre
Ekaterina V. Sheremetyeva, MD, PhD
Moscow
SPIN-код: 9413-5136
Yu. S. Absatarova
Endocrinology research centre
Yulia S. Absatarova, MD, PhD
Moscow
SPIN-код: 2220-9464
N. G. Mokrysheva
Endocrinology research centre
Natalya G. Mokrysheva, MD, PhD, Professor
Moscow
SPIN-код: 5624-3875
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For citations:
Mikheev R.K., Grigoryan O.R., Pankratova M.S., Andreeva E.N., Sheremetyeva E.V., Absatarova Yu.S., Mokrysheva N.G. Telomere pathology in ontogenesis in patients with Turner syndrome. Problems of Endocrinology. 2022;68(2):128-132. (In Russ.) https://doi.org/10.14341/probl12869
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