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Arterial mediacalcinosis in patients with diabetes mellitus: etiopathogenetic and histopathological aspects

https://doi.org/10.14341/probl13360

Abstract

In a review of the generalized results of foreign and domestic studies on the development mechanism and pathogenesis of vascular calcification. The etiopathogenetic, pathophysiological and histomorphological features of mediacalcinosis, which reveal changes in the vascular bed in patients with DM, are considered. The role of risk factors for diseases, such as increased glycemia, changes in insulin levels, impaired lipid metabolism, obesity, arterial hypertension, CKD and aging, is indicated. The role of procalcifying and anticalcifying factors in colonic vascular remodeling is discussed. Identification of informative molecular markers and factors of CS will allow in the future to develop effective strategies for drug management of the risk of their progression and individual prevention programs to improve the quality and life expectancy in patients with cardiovascular diseases.

About the Authors

O. N. Bondarenko
Endocrinology Research Centre
Russian Federation

Olga N. Bondarenko, MD, PhD

Moscow, Russia, 11, Dm. Uliyanova str., Moscow, 117292


M. V. Yaroslavceva
Endocrinology Research Centre
Russian Federation

Marianna V. Yaroslavceva, MD, PhD

Moscow


G. R. Galstyan
Endocrinology Research Centre
Russian Federation

Gagik R. Galstyan, MD, PhD, Professor

Moscow


N. G. Mokrysheva
Endocrinology Research Centre
Russian Federation

Natalia G. Mokrysheva, MD, PhD, Professor

Moscow


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Supplementary files

1. Figure 1. Echogram. B-mode. Calcification of the wall of the posterior tibial artery in a 73-year-old patient with type 2 diabetes for more than 20 years and chronic renal failure.
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2. Figure 2. Photographs. Calcified dorsal metatarsal artery of the foot in the 1 interphalangeal space (surgical material).
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Type Исследовательские инструменты
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3. Figure 3. X-ray of the foot. Calcification of the arteries of the foot (indicated by arrows)
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Type Исследовательские инструменты
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Review

For citations:

Bondarenko O.N., Yaroslavceva M.V., Galstyan G.R., Mokrysheva N.G. Arterial mediacalcinosis in patients with diabetes mellitus: etiopathogenetic and histopathological aspects. Problems of Endocrinology. 2025;71(1):50-59. (In Russ.) https://doi.org/10.14341/probl13360

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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