The clinical case of IgG4-related thyroid disease in a 6-year-old child
A. A. Kolodkina,
N. A. Zubkova,
L. S. Urusova,
S. P. Bondarenko,
D. N. Brovin,
A. V. Anikiev,
O. B. Bezlepkina https://doi.org/10.14341/probl13379
Abstract
IgG4-related disease is a rare chronic pathology manifested by lymphoplasmacytic infiltration of one or more organs, the formation of storiform fibrosis, tissue edema, and an increase of IgG4 in the blood. This disease was singled out as an independent nosological unit only in 2001. The incidence is less than 1 in 100,000 people per year. Almost any organ can be affected in IgG4-related disease. The association of Riedel's thyroiditis with IgG4 was established in 2010. Riedel's thyroiditis is an extremely rare inflammatory disease of the thyroid gland, which diagnosis is complicated by an atypical course and the absence of characteristic symptoms. Less than 300 clinical cases of the disease have been described in the world, only two from them were in children. This article presents a clinical case of a 6-year-old boy with Riedel's thyroiditis.
About the Authors
A. A. Kolodkina
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Anna A. Kolodkina, MD, PhD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
N. A. Zubkova
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Natalia A. Zubkova, MD, PhD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
L. S. Urusova
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Liliya S. Urusova, MD, PhD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
S. P. Bondarenko
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Sofiia P. Bondarenko
11 Dm. Ulyanova street, 117036 Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
D. N. Brovin
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Dmitriy N. Brovin, MD, PhD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
A. V. Anikiev
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Alexander V. Anikiev, MD, PhD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
O. B. Bezlepkina
Endocrinology Research Center
Russian Federation
Competing Interests:
Russian Federation
Olga B. Bezleрkina, MD
Moscow
Competing Interests:
Автор декларирует отсутствие явных и потенциальных конфликтов интересов, связанных с содержанием настоящей публикации.
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Supplementary files
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1. Figure 1. Nodule in the left lobe of the thyroid gland (circled) with hyperechoic inclusions from 0.1 to 0.5 cm (indicated by arrows). | |
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2. Figure 2. A. Macropreparation of the left lobe of the thyroid gland. Arrows indicate the focus of fibrotic changes. B. Macropreparation of the right lobe of the thyroid gland. The structure has not been changed. | |
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3. Figure 3. Schematic representation of the ingrowth of fibrous tissue into the surrounding structures of the neck. | |
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4. Figure 4. Microscopic examination of the surgical material of the left lobe of the thyroid gland: a - fibrous tissue; b - area of granulomatous inflammation; c - unfused thyroglossal duct; d - infiltration of giant multinucleated cells, lymphocytes with an admixture of neutrophils. Staining with hematoxylin and eosin x50. | |
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5. Figure 5. Microscopic examination of the surgical material, the affected area of skeletal muscle: a - fibrous tissue; b — obliterating phlebitis. Hematoxylin and eosin staining x100 | |
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6. Figure 6. Immunohistochemical study of surgical material with antibodies CD68, CD138, IgG, IgG4, a positive reaction was revealed: A - CD68 (macrophages). Magnification x50; B - CD138 (plasma cells). Magnification x50; B - IgG-positive plasma cells. Magnification x50; D - IgG4-positive plasma cells. Magnification x50. | |
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For citations:
Kolodkina A.A., Zubkova N.A., Urusova L.S., Bondarenko S.P., Brovin D.N., Anikiev A.V., Bezlepkina O.B. The clinical case of IgG4-related thyroid disease in a 6-year-old child. Problems of Endocrinology. 2024;70(2):94-102. (In Russ.) https://doi.org/10.14341/probl13379
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