Cognitive impairment in patients with obesity and impaired carbohydrate metabolism (dysglycemia)
https://doi.org/10.14341/probl13389
Abstract
Obesity is a chronic disease, heterogeneous in etiology and clinical manifestations, progressing with a natural course, characterized by excessive deposition of fat mass in the body. This pathological condition has taken on the scale of a global epidemic in recent years, which continues to progress steadily, currently affecting more than 2 billion people worldwide. Due to its heterogeneity, obesity has a negative impact on the work of almost all organs and systems of the body, contributing to the emergence of new concomitant diseases and pathological conditions that significantly worsen the quality of life of these patients. Thus, a close relationship between type 2 diabetes mellitus and cognitive impairment has long been known, as well as with a number of other somatic diseases: coronary heart disease, atherosclerosis, non-alcoholic fatty liver disease, dyslipidemia, malignant neoplasms and other associated pathological conditions against the background of overweight and obesity.
Currently, the problem of the relationship of cognitive impairment in patients with overweight or changes in the glycemic profile is very relevant, due to the high prevalence and insufficient study of this issue.
About the Authors
F. Kh. Dzgoeva
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Fatima Kh. Dzgoeva - MD, PhD.
Moscow
Competing Interests:
none
E. V. Ekusheva
Academy of Postgraduate Education of the Federal Research and Clinical Centre for Specialized Medical Care and Medical Technologies; Belgorod State National Research University
Russian Federation
Competing Interests:
Russian Federation
MD, PhD, Professor.
Moscow, Belgorod
Competing Interests:
none
V. V. Demidova
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Viktoria Demidova
11 Dm.Ulyanova street, 117036 Moscow
Competing Interests:
none
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Supplementary files
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1. Figure 1. Decreased volume of gray and white matter in the frontal lobes, anterior cingulate gyrus (a — blue arrow), hippocampus (b — black arrow) and basal ganglia (c — green frame) in obese patients according to magnetic resonance morphometry. | |
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2. Figure 2. The role of obesity in the development of systemic inflammation and mitochondrial dysfunction. | |
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3. Figure 3. The main mechanisms of insulin influence on the pathogenesis of Alzheimer's disease [23]. | |
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4. Figure 4. The role of insulin resistance and insulin deficiency in the development of Alzheimer's disease [25]. | |
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For citations:
Dzgoeva F.Kh., Ekusheva E.V., Demidova V.V. Cognitive impairment in patients with obesity and impaired carbohydrate metabolism (dysglycemia). Problems of Endocrinology. 2024;70(4):75-83. (In Russ.) https://doi.org/10.14341/probl13389
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