Стресс эндоплазматического ретикулума: цитологический сценарий патогенеза заболеваний человека

Феномен "стресса" эндоплазматического ретикулума (ЭР) привлекает все большее внимание. Современные данные позволяют рассматривать дисфункцию ЭР как общее звено многих заболеваний человека, среди них - онкопатология, нейродегенеративные и вирусные заболевания. Особое значение перегрузка ЭР имеет для клеточных популяций, активно секретирующих белок, поскольку для развития стресса ЭР огромное значение имеет нарушение фолдинга белка. Это обстоятельство может сформировать новое понимание такого заболевания, как сахарный диабет. В данной работе обобщаются современные представления о биохимических основах стресса ЭР и рассматриваются ключевые сигнальные пути компенсации и проапоптоза.

стресс эндоплазматического ретикулума, фолдинг белка, сахарный диабет, сигнальные пути

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