The level of vitamin D and its relationship with the amount of fatty tissue and adipocytokine content in the women of reproductive age
https://doi.org/10.14341/probl201258619-23
Abstract
The patients with obesity are known to suffer 25-hydroxy vitamin D (25(OH)D) deficiency, but the relationship between these two conditions remains unclear. The blood 25(ON)D levels in practically healthy women were compared with the amount and distribution patterns of the fatty tissue and with the content of plasma adipocytokines. The absence or deficit of vitamin D was documented in 61.3% of the women included in the present study. They exhibited negative correlation between 25(ON) D levels and body weight. The patients with obesity were characterized by correlation between the 25(ON)D levels and waist circumference, body weight, BMI, and the amount of fatty tissue. The women of reproductive age with the reduced blood 25(ON)D level (OR 1.86 [0.88—3.95]; CI 95%) or 25(ON)D deficiency (OR 2.23 [1.03—4.80]; CI 95%) were at a higher risk of development of obesity compared with the women in whom the 25(ON)D levels were in excess of 75 nmol/l. The study confirmed correlations between adypocytokine levels and the amount of fatty tissue even though it failed to demonstrate a significant relationship between the levels of adipocytokines and vitamin D.
About the Authors
T. L. Karonova
Almazov Federal Heart, Blood and Endocrinology Centre, Saint-Petersburg
Russian Federation
Russian Federation
E. N. Grineva
Almazov Federal Heart, Blood and Endocrinology Centre, Saint-Petersburg
Russian Federation
Russian Federation
E. P. Mikheeva
Saint-Petersburg State Pavlov Medical University, Saint-Petersburg
Russian Federation
Russian Federation
O. D. Belyaeva
Saint-Petersburg State Pavlov Medical University, Saint-Petersburg
Russian Federation
Russian Federation
E. I. Krasil’nikova
Saint-Petersburg State Pavlov Medical University, Saint-Petersburg
Russian Federation
Russian Federation
I. L. Nikitina
Saint-Petersburg State Pavlov Medical University, Saint-Petersburg
Russian Federation
Russian Federation
References
1. Yach D., Struckler D., Brownell K.D. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 2006; 12: 62—66.
2. Adams J.S., Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010; 95: 471—478.
3. Holick M.F. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006; 81: 3: 353—373.
4. Каронова Т.Л., Михеева Е.П., Красильникова Е.И., Беляева О.Д., Буданова О.Д., Галкина О.В., Гринева Е.Н. Дефицит витамина D — фактор риска развития ожирения и сахарного диабета 2 типа у женщин репродуктивного возраста. Артериальная гипертензия 2012; 18: 1: 25—32.
5. Heaney R.P. Vitamin D in health and disease. Clin J Am Soc Nephrol 2008; 3: 1535—1541.
6. Chiu K.C., Chu A., Go V.L.W., Saad M. Hypovitaminosis D is associated with insulin resistance and s cell dysfunction. Am J Clin Nutr 2004; 79: 820—825.
7. McGill A.T., Stewart J.M., Lithander F.E., Strik C.M., Poppitt S.D. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J 2008; 7: 1—5.
8. Kull M., Kallikorm R., Lember M. Body mass index determines sunbathing habits: implications on vitamin d levels. Intern Med J 2009; 39: 256—258.
9. Fontana L., Eagon J.C., Trujillo M.E., Scherer P.E., Klein S. Visceral fat adipokine secretion is associated with systemic infl ammation in obese humans. Diabetes 2007; 56: 1010—1013.
10. Kong J., Li Y.C. Molecular mechanism of 1,25-dihydroxyvitamin D3 ingibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab 2006; 290: E916—E924.
11. Ljunghall S., Lind L., Lithell H., Skarfors E., Selinus I., Sorensen O.H., Wide L. Treatment with one-alpha-hydroxycholecalciferol in middle-age men with impaired glucose tolerance – a prospective randomized double-blind study. Acta Med Scand 1987; 222: 361—367.
12. Ortega R.M.., Lopez-Sobaler A.M., Aparicio A., Bermejo L.M., Rodriguez-Rodriguez E., Perea J.M., Andres P. Vitamin D status modify cation by two slightly hypocaloric diets in young overweight/obese women. Int J Vitam Nutr Res 2009; 79: 71—78.
13. Wortsman J., Matsuoka L.Y., Chen T.C., Lu Z., Holick M.F. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690—693.
14. International Diabetes Federation. Worldwide defi nition of the metabolic syndrome. Available at: http://www.idf.org/webdata/docs/IDF_Metasyndrome_difinition
15. Hans D., Genton L., Conicella G., Karsegard V., Pichard C., Slosman D. Half-body DXA scan predicts whole body composition: a potential method to measure overweight patients. Clin Nutr 2001; 20: Suppl 3: 1.
16. Kelly T., Wilson K., Heymsfi eld S. Dual Energy X-ray absorbtiometry body composition reference values from NHANES. PloS ONE 2009; 4: 9:e7038.
17. Holick M.F. Vitamin D Defi ciency. New Engl J Med 2007; 357: 3: 266—281.
18. Looker A.C., Johnson C.L., Lacher D.A., Pfeiff er C.M., Schleicher R.L., Sempos C.T. Vitamin D status: United States, 2001—2006. NCHS data brief, no 59. Hyattsville: National Center for Health Statistics 2011.
19. Matsuzawa Y., Funahashi T., Kihara S., Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004; 24:29—33.
20. Targher G., Bertolini L., Scala L., Zoppini G., Zenari L., Falezza G. Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals. Clin Endocrinol 2004; 61: 700—703.
21. Беляева О.Д., Баженова Е.А., Березина А.В., Большакова О.О., Чубенко Е.А., Гаранина А.Е, Баранова Е.И., Беркович О.А., Шляхто Е.В. Уровень адипонектина, показатели липидного и углеводного обменов у пациентов с абдоминальным ожирением. Артериальная гипертензия 2009; 15: 3: 309—314.
22. Manson J.E., Skerrett P.J., Greenland P., Vanltallie T.B. The escalating pandemic of obesity and sedendary lifestyle. A call to action for clinicians. Arch Intern Med 2004; 164: 3: 249—258.
23. Blum M., Dolnikowski G., Seyoum E., Susan S.H. Vitamin D(3) in fat tissue. Endocr Rev 2008; 33: 90—94.
24. Kull M., Kallikorm R., Lember M. Body mass index determines sunbathing habits: implications on vitamin d levels. Intern Med J 2009; 39: 256—258.
25. De Paula F.J.A., Rosen C.J. Vitamin D and fat In Vitamin D. Eds. D. Feldman, J.W. Pike, J.S. Adams. Academic Press 2011; 769—776.
Review
For citations:
Karonova T.L., Grineva E.N., Mikheeva E.P., Belyaeva O.D., Krasil’nikova E.I., Nikitina I.L. The level of vitamin D and its relationship with the amount of fatty tissue and adipocytokine content in the women of reproductive age. Problems of Endocrinology. 2012;58(6):19-23. (In Russ.) https://doi.org/10.14341/probl201258619-23
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