Novel approaches of glucose-lowering therapy in type 2 diabetes and chronic kidney disease
https://doi.org/10.14341/probl201561636-43
Abstract
Frequency of the diabetes mellitus (DM) and chronic kidney disease (CKD) steadily increases around the world. Compensation of a carbohydrate metabolism plays a key role in prevention of development and progressing of CKD in patients with DM, that was proved in the largest researches. However at later stages of CKD compensation of a carbohydrate metabolism is extremely complicated because of high risk of hypoglycemia due to decrease in a renal gluconeogenesis, insulin and anti-hyperglycemic agents cumulation, inadequate level of glycated hemoglobin due to nephrogenic anemia. Thus, great care and an individual approach in choosing and intensification of hypoglycemic therapy are required in patients with diabetes. Incretin drugs have taken a worthy place in the international and national guidelines for the treatment of patients with type 2 diabetes mellitus (DM2). Inhibitors of dipeptidyl peptidase-4 (DPP-4) showed a favorable efficacy and safety profile in patients with normal renal function and patients with CKD.
About the Authors
Natalya Petrovna Trubitsyna
Endocrinology Research Centre
Russian Federation
MD, PhD
Russian Federation
MD, PhD
Anastasia Sergeevna Severina
Endocrinology Research Centre
Russian Federation
MD, PhD, senior reseacher of diabetic nephropaty
Russian Federation
MD, PhD, senior reseacher of diabetic nephropaty
Shamkhalova Shamkhalovna Minara
Endocrinology Research Centre
Russian Federation
MD, PhD
Russian Federation
MD, PhD
Marina Vladimirovna Shestakova
Endocrinology Research Centre; Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Professor, Director of Diabetes institute
Russian Federation
MD, PhD, Professor, Director of Diabetes institute
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Review
For citations:
Trubitsyna N.P., Severina A.S., Minara Sh.Sh., Shestakova M.V. Novel approaches of glucose-lowering therapy in type 2 diabetes and chronic kidney disease. Problems of Endocrinology. 2015;61(6):36-43. https://doi.org/10.14341/probl201561636-43
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