Modern approaches to the treatment of Cushing’s disease
https://doi.org/10.14341/probl201662450-55
Abstract
Traditionally the Cushing’s disease (CD) is considered a rare disease. Since 2012 СD has the official status of an orphan disease in the Russian Federation. Now prevalence of this disease in the world are from 1,5 to 3,9 cases of CD on 1 million people of the population. The reason of CD is the adenoma of a hypophysis (сortiсotropinoma). The “gold” standard of therapeutic tactics of patients with CD is the transsphenoidal surgery. However in 20% of cases after the radical treatment fail to achieve remission of pathological process. Now in an arsenal of the neuroendocrinologist we have various methods of therapy, including various methods of drug therapy. The focus of preparations are central type action: analogs of a somatostatin. The representative of this group of preparations is Pasireotid who has proved the efficiency by results of the multicenter clinical trials. This review focuses of the current state of knowledge about methods of treatment of CD, about new therapeutic opportunities with application of analogs of a somatostatin.
About the Authors
Anna V. Andreeva
Endocrinological dispansery Health Care Department;
City Clinical Hospital named after V.V. Veresaev
Russian Federation
MD,PhD
Competing Interests:
Russian Federation
MD,PhD
Competing Interests:
No conflict of interest
Natal'ja V. Markina
Endocrinological dispansery Health Care Departmen
Russian Federation
MD,PhD
Competing Interests:
Russian Federation
MD,PhD
Competing Interests:
No conflict of interest
Mihail B. Antsiferov
Endocrinological dispansery Health Care Departmen
Russian Federation
MD,PhD
Competing Interests:
Russian Federation
MD,PhD
Competing Interests:
No conflict of interest
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Andreeva A.V., Markina N.V., Antsiferov M.B. Modern approaches to the treatment of Cushing’s disease. Problems of Endocrinology. 2016;62(4):50-55. (In Russ.) https://doi.org/10.14341/probl201662450-55
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