Phenotyping animal models of diabetic peripheral neuropathy in rats: advantages and limitations
Zera N. Abdulvapova,
Ekaterina V. Artemova,
Anna M. Gorbacheva,
Gagik R. Galstyan,
Alla Yu. Tokmakova,
Svetlana A. Gavrilova https://doi.org/10.14341/probl9284
Abstract
Diabetic polyneuropathy is one of the most common late complications of diabetes mellitus, as well as the main cause of ulcerative foot defects. The prevalence of neuropathy among people with diabetes varies from 28 to 65%, depending on the disease duration and diagnostic features. Initial signs of damage are detected as early as in prediabetes. To date, there is a fairly limited knowledge of the mechanisms of nerve fiber damage in diabetes. Also, it is unclear which type of nerve fibers is involved in damage first and how the nervous system regulates repair of tissues and local immunity. Animal models of diabetic peripheral neuropathy enable studying new aspects of the pathogenesis of this common diabetes complication and open prospects for the search and development of new drugs.
About the Authors
Zera N. AbdulvapovaEndocrinology Research Centre
Russian Federation
MD
Ekaterina V. Artemova
Endocrinology Research Centre
Russian Federation
MD
Anna M. Gorbacheva
Lomonosov Moscow State University
Russian Federation
MD
Gagik R. Galstyan
Endocrinology Research Centre
Russian Federation
PhD, professor
Alla Yu. Tokmakova
Endocrinology Research Centre
Russian Federation
PhD
Svetlana A. Gavrilova
Lomonosov Moscow State University
Russian Federation
PhD
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Review
For citations:
Abdulvapova Z.N., Artemova E.V., Gorbacheva A.M., Galstyan G.R., Tokmakova A.Yu., Gavrilova S.A. Phenotyping animal models of diabetic peripheral neuropathy in rats: advantages and limitations. Problems of Endocrinology. 2018;64(3):188-193. https://doi.org/10.14341/probl9284
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