Biological properties of hepoxylines
https://doi.org/10.14341/probl10386
Abstract
Hepoxylines, arachidonic acid metabolites, are present in many tissues of the body and regulate various cell functions. We investigated the biological effects of hepoxylines B3 (10R and 10S epimers) on the secretory processes using primary cultures of rat pancreatic islet cells, adenohypophyseal ceils, and hepatocytes. Hepoxylines added to culture medium boosted the secretion of insulin and serum albumin and inhibited prolactin secretion. Hepoxyline effect on insulin secretion did not depend on the presence of glucose in the medium. Experiments on a model of type 11 diabetes showed that exogenous hepoxylines partially repair the islet cell sensitivity to glucose. Impaired synthesis of hepoxylines and their metabolism or receptor interactions with pancreatic p-cells may be one pathogenetic factor in the development of non-insulindependent diabetes mellitus. In order to verify this hypothesis, methods and agents boosting and inhibiting the production of endogenous hepoxylines are needed and the effects of hepoxylines on tissues resistant to insulin because of type II diabetes are to be studied.
About the Authors
V. P. FedotovLaboratory of biological studies of hormonal compounds
Russian Federation
N. V. Sadovnikova
Russian Federation
V. I. Gudoshnikov
Russian Federation
I. N. Baranova
Russian Federation
L. L. Vasilyeva
Russian Federation
К. K. Pivnitsky
Лаборатории химии стероидов и простагландинов
Russian Federation
References
1. Абрамова В. В., Федотов В. П. // Пробл. эндокринол. — № 2. — С. 68—73.
2. Пивницкий К. К. II Журн. Всесоюз. хим. о-ва. им. Д. И. Менделеева. — 1991. — Т. 36, № 4. — С. 418—422.
3. Плужникова Г. Н.. Кондратьев Я. Ю. // Пробл. эндокринол. - 1985. - № 2. - С. 58-63.
4. Bevan S., Wood J. N. // Nature. — 987. — Vol. 328. — P. 20.
5. Capdevila J., Parkhill L., Chacos N. et al. // Biochem. biophys. Res. Commun. — 1981. — Vol. 101. — P. 1357—1363.
6. Corey E. J., Kang J., Laguzza В. C. et al. // Tetrahedron. - Vol. 24. - P. 4913-4916.
7. Demin P. M.. Reynaud D.. Pace-Asciak C. R. // J. Lipid Mediators Cell Signalling. — 1996. — Vol. 13. - P. 63-72.
8. Dho S., Grinstein S., Corey E. J. et al. // Biochem. J. — 1990. - Vol. 266. - P. 63-68.
9. Keisel L.. Przylipiak A., Rabe T. et al. // Hum. Reprod. — 1987. - Vol. 2. - P. 281.
10. Margalit A., Sofer J.. Grossman S. et al. // Proc. natl. Acad. Sci. USA. - 1993. - Vol. 90. - P. 2589-2592.
11. Metz S. /I Ibid. - 1985. - Vol. 82. - P. 198-202.
12. Nathan M. N.. Pek S. B. // Prostagland. Leukotr., Essent. Fatty Acids. — 1990. — Vol. 40. — P. 21—25.
13. Nigam S.. Nodes S., Cichon G. et al. // Biochem. biophys. Res. Commun. — 1990. — Vol. 171. — P. 944-948.
14. Pace-Asciak C. R.. Granstrom E., Samuelsson B. // J. biol Chem. - 1983. — Vol. 258. - P. 6835-6840.
15. Pace-Asciak C. R.. Martin J. M. // Prostagland. Leukotr. Med. - 1984. - Vol. 16. - P. 173-180.
16. Pace-Asciak C. R.. Asotra S. // Free Radical Biol. Med. — 1989. - Vol. 7. - P. 409-433.
17. Pace-Asciak C. R. // Biochim. biophys. Acta. — 1994. — Vol. 1215. - P. 1-8.
18. Pivnitsky К. K., Vasiljeva L. L., Melnikova V. I. // American Chemical Society. National Meeting, 207-th: Book of Abstracts. — San Diego, 1994. — N 84.
19. Portha B., Blondel O., Serdadas P. et al. // Diabet. Metab. (Paris). - 1989. - Vol. 15. — P. 61-75.
20. Reynaud D.. Delton I.. Gharib A. et al. // J. Neurochem. — 1994. - Vol. 62. - P. 126-133.
21. Reunaud D.. Demin P.. Pace-Asciak C. R. // Biochem. biophys. Res. Commun. — 1995. — Vol. 207. — P. 191 — 194.
22. Turk J.. Colca J. R.. McDaniel M. L. // Biochim. biophys. Acta. - 1985. - Vol. 834. - P. 23-36.
23. Vasiljeva L. L.. Manukina T. A., Demin P. M. et al. // Tetrahedron. - 1993. - Vol. 49. — P. 4099-4106.
Review
For citations:
Fedotov V.P., Sadovnikova N.V., Gudoshnikov V.I., Baranova I.N., Vasilyeva L.L., Pivnitsky К.K. Biological properties of hepoxylines. Problems of Endocrinology. 1997;43(3):8-12. (In Russ.) https://doi.org/10.14341/probl10386
Views:
9898
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
