Prospects in the treatment of diabetic nephropathy
https://doi.org/10.14341/probl10389
Abstract
The authors discuss new approaches to the treatment and prevention of diabetic nephropathy based on elimination of the pathogenetic factors of its development. Hyperglycemia, the main triggering factor of vascular complications of diabetes mellitus. induces a cascade of other pathological reactions, such as renal dysfunction, biochemical and structural changes in the basal membranes of renal capillaries, and stimulates the secretion of vasoactive factors of vascular endothelium and platelets. Blocking of these reactions by specific agents inhibits the progress of diabetic nephropathy. The authors share their experience gained in the treatment of diabetic nephropathy with inhibitors of angiotensin-converting enzyme, glycosaminoglycanes, and thromboxane synthesis inhibitors. These drugs are more effective if prescribed at the early stages of diabetic involvement of the kidneys.
About the Authors
M. V. ShestakovaEndocrinology Research Center
Russian Federation
A. V. Vorontsov
Endocrinology Research Center
Russian Federation
S. G. Vykhristyuk
Endocrinology Research Center
Russian Federation
I. I. Dedov
Endocrinology Research Center
Russian Federation
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Review
For citations:
Shestakova M.V., Vorontsov A.V., Vykhristyuk S.G., Dedov I.I. Prospects in the treatment of diabetic nephropathy. Problems of Endocrinology. 1997;43(3):20-22. (In Russ.) https://doi.org/10.14341/probl10389
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