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Problems of Endocrinology

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Effect of glucocorticoids and catecholamines on the state of the tissue lysosomal apparatus in rabbits with experimental diabetes

https://doi.org/10.14341/probl198228170-73

Abstract

Administration to rabbits of hydrocortisone (8 mg/kg) and adrenaline (0.3 ml of 0.1% solution) during mild dithizone diabetes simulated hormonal reconstructions of the body exposed to stress. Activation of the cellular lysosomal apparatus occurs in such hormonal situation. In the liver this in manifested by an increase in the acid phosphatase, cathepside D, and beta-glucosidase free activity and by reduction in the resistance of lysosomal membranes to the effect of osmotic shock. Increase in the total acid hydrolase activity was detected in the cardiac and skeletal muscles.

About the Authors

L E Panin
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences


T K Klimenteva
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences


N N Mayanskaya
Research Center for Clinical and Experimental Medicine or Scientific Centre of Clinical and Experimental Medicine under the Siberian Branch of the Russian Academy of Medical Sciences


References

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3. Burstone М. S. Enzyme Histochemistry and Applications in the Study of Neoplasm. New York, 1962. p. 164-168.

4. Панин Л. E., Маянская H. H. -Бюлл. экспер. биол., 1977, № 6, с. 678-680.

5. Панин Л. Е., Маянская Н. П., Климентьева Т.К. -В кн.: Всесоюзная конф. по биохимии мышц. 3-я. Тезисы докладов. М., 1978, с. 47-48.

6. Панин Л. Е., Маянская Н. Н., Климентьева Т. К. -В кн.: Всесоюзный симпозиум по медицинской энзимологии. 3-й. Тезисы докладов. Астрахань, 1979, с. 98.


Review

For citations:


Panin L.E., Klimenteva T.K., Mayanskaya N.N. Effect of glucocorticoids and catecholamines on the state of the tissue lysosomal apparatus in rabbits with experimental diabetes. Problems of Endocrinology. 1982;28(1):70-73. https://doi.org/10.14341/probl198228170-73

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)