The content of dehydroepiandrosterone, testosterone and cortisol in newly diagnosed type II diabetes mellitus

The aim of the study was to investigate the levels of testosterone (T), hydrocortisone (HC), and dihydroepiandrosterone (DEA) in patients with type 2 diabetes immediately after diagnosis of the disease and after 30-day diet and sulfonurea therapy. Three groups of patients were distinguished: A) 6 males aged 62.0+3.03 years, B) 15 females aged 63.5+1.69 years who achieved good metabolic control, and C) 4females aged 51.5+6.42years whose treatment was ineffective. The levels of DEA increased significantly in the A and В groups in comparison with the pre-treatment levels. The T level increased to 9.82+0.91 in group A vs. the initial 5.28+0.79 nmol/liter, p<0.01. By contrast, group В showed a decrease in T level to 0.68+0.15 vs. the initial 1.4+0.21 nmol/liter, p<0.02. A decrease in DHA to 6.23+1.53 vs. the initial 13.25+1.72 nmol/liter was observed in group C, while the decrease in the level of T was negligible. Basal insulinemia decreased over the period of follow-up in all patients. Hence, our findings demonstrate that the achievement of a good metabolic status in newly diagnosed diabetics with type 2 condition is associated with an increase in DHA level both in men and women, while the changes in the level of T are determined by the gender. A poor metabolic status results in a positive relationship between the DHA and insulin levels in male patients with hyperinsulinemia, while in female subjects this relationship depends on the basal insulin level.

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