The role of oxidative stress in the pathogenesis of vascular complications of diabetes (lecture)
https://doi.org/10.14341/probl200046629-34
Abstract
Vascular complications of diabetes are the main cause of disability and mortality. That is why the efforts of numerous scientific laboratories and scientists are aimed at elucidating the mechanisms of the pathogenesis of these disorders.
The results of many studies, and in particular, DCCT (The Diabetes Control and Complication Trial) indicate that hyperglycemia is one of the main causes of the development of late vascular complications of diabetes. Chronic hyperglycemia initiates the development of changes in the vascular wall using several mechanisms: by activating the polyol pathway of glucose metabolism, glycosylation of various proteins, oxidative stress, etc.
About the Authors
M. I. BalabolkinEndocrinology Research Centre
Russian Federation
E. M. Klebanova
Endocrinology Research Centre
Russian Federation
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Review
For citations:
Balabolkin M.I., Klebanova E.M. The role of oxidative stress in the pathogenesis of vascular complications of diabetes (lecture). Problems of Endocrinology. 2000;46(6):29-34. (In Russ.) https://doi.org/10.14341/probl200046629-34
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