Urinary excretion of sulfated glycosamines in patients with diabetic nephropathy
https://doi.org/10.14341/probl200147435-38
Abstract
The urine content and fraction composition of sulfated glycosaminoglycanes (GA G) were studied in 55 diabetics (48 with type I and 9 with type 2 diabetes) with different stages of diabetic nephropathy (DN) and 25 donors. A marked increase (2.5 times) of GAG excretion was revealed in diabetics. Urinary GAG level and glycemic control values were in positive correlation. Urinary GAG levels were the highest in the patients with DN. GAG fraction composition depended on the nephropathy stage. In patients without DN, like in healthy controls, the basic GA G fraction was chondroitine sulfate. In patients with initial DN heparan sulfate excretion was increased in 90.3% and dermatan sulfate excretion in 23.3fo cases. In the group with proteinuria the excretion of these fractions was observed in 91.7 and 25%) patients, respectively. These results indicate essential disorders in GAG-containing proteoglycane metabolism in diabetics and suggest that these disorders contribute to development of nephropathy. Study of urinary GAG fractions can be used in early diagnosis of DN.
About the Authors
I. A. BondarNovosibirsk State Medical Academy; Novosibirsk Regional Diagnostic Center
Russian Federation
V. V. Klimontov
Novosibirsk State Medical Academy; Novosibirsk Regional Diagnostic Center
Russian Federation
G. A. Paul
Novosibirsk State Medical Academy; Novosibirsk Regional Diagnostic Center
Russian Federation
S. M. Ambrosova
Novosibirsk State Medical Academy; Novosibirsk Regional Diagnostic Center
Russian Federation
T. A. Korolenko
Novosibirsk State Medical Academy; Novosibirsk Regional Diagnostic Center
Russian Federation
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Review
For citations:
Bondar I.A., Klimontov V.V., Paul G.A., Ambrosova S.M., Korolenko T.A. Urinary excretion of sulfated glycosamines in patients with diabetic nephropathy. Problems of Endocrinology. 2001;47(4):35-38. (In Russ.) https://doi.org/10.14341/probl200147435-38
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