Current techniques for diagnosis of diabetic macroangiopathy
https://doi.org/10.14341/probl200551339-43
Abstract
The present paper deals with the epidemiology, pathogenesis, and diagnosis of peripheral diabetic macroangiopathy. A total of 102 patients (51 males and 51 females) aged 45 to 74 years (mean 63.4 ± 4.0years) who had type 2 diabetes mellitus (DM) and clinical manifestations of coronary heart disease (CHD) were examined to study endothelial function and the degree and extent ofocclusive lesions in the lower extremity arteries in the neuropathic and neuroischemic forms of the diabetic foot. The study of endothelial function in the reactive hyperemia test demonstrated a significant reduction inflow-dependent vasodilatation in all the examined patients with type 2 DM and CHD as compared with gender- and age-matched CHD patients without carbohydrate metabolic disorders. This is mostly characteristic for patients with type 2 DM, CHD, and femoropopliteal atherosclerosis who showed a 2-fold decrease in flow-dependent vasodilatation as compared with the control patients. Endothelial function more significantly impaired as the severity and extent of diabetic macroangiopathy increased.
About the Authors
A. Yu. TokmakovaEndocrinology Research Centre
Russian Federation
D. N. Staroverova
Endocrinology Research Centre
Russian Federation
References
1. Балахонова Т.В. Ультразвуковое исследование артерий у пациентов с сердечно-сосудистыми заболеваниями: Дис.... д-ра мед. наук. - М., 2002.
2. Дедов И.И., Анциферов М.Б., Галстян Г.Р., Токмакова А.Ю. Синдром диабетической стопы. -М., 1998.
3. Дедов И.И., Шестакова М.В. Сахарный диабет. - М., 2003.
4. Кунцевич Г. И., Барабашкина А. В., Белолапотко Е. А., Гаврилин А. В., Жестовская С. И., Журенкова Т. В., Кусова Ф. У., Скуба Н. Д., Тер-Хачатурова И. Е., Темерова Н. В., Шутихина И. В. Ультразвуковая диагностика в абдоминальной и сосудистой хирургии. Минск: Кавалер Паблишерс, 1999. 256с.
5. Corretti M.С., Anderson T.J., Benjamin E.J. et al. //J. Am. Coll. Cardiol. -2002. -Vol.39. -P. 257-265.
6. Enderle M.D., Benda N., Schmuelling R.M. et al. // Diabetes Care. -1998. -Vol.21. -P. 271-277.
7. Feener E.P., King G.L. // Lancet. -1997. -Vol.350. -Suppl.1. -P. 9-13.
8. Howard G., Sharrett A.R., Heiss G. et al.//Stroke. -1993. -Vol.24. -P. 1297-1304.
9. Kenneth O.//Lancet. -2001. -Vol.358. -P. 1257-1264.
10. Levin M.E., O'Neal S. // The Diabetic Foot/Eds J.H. Bowker, M.A. Pfeifer. -6-th Ed. -St. Louis, 2001. 43
11. Luscher T.F., Tanner F.C., Noll G. // Curr. Opin. Lipid. -1996. -Vol.7. -P. 234-240.
12. McKenney J.M. // J. Am. Pharm. Assoc. -2001. -Vol.41, № 4. -P. 596-607.
13. Otsuki M., Hashimoto K., Morimoto Y. et al. // Diabetes. -1997. -Vol.46. -P. 2096-2101.
14. Selwyn A.P., Kinlay S., Ganz P. // Am. J. Cardiol. -1997. -Vol.80. -P. 3-7.
15. Wakabayashi Y., Fujita H., Fujimoto K. et al. // Platelets. -1995. -Vol.6. -P. 176-182
Review
For citations:
Tokmakova A.Yu., Staroverova D.N. Current techniques for diagnosis of diabetic macroangiopathy. Problems of Endocrinology. 2005;51(3):39-43. (In Russ.) https://doi.org/10.14341/probl200551339-43
Views:
649
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
