Microalbuminuria in patients with type 2 diabetes mellitus and arterial hypertension: Possibilities of therapy
https://doi.org/10.14341/probl20055142-6
Abstract
The study covered 30 patients with type 2 diabetes mellitus associated with mild and moderate arterial hypertension and beginning diabetic nephropathy (Stage III in accordance with the classification developed by C. Mogensen). The purpose of the study was to evaluate the therapeutic effect of the new superselective fi-blocker nebivolol (nebilet) having NO-modulating activity on the patho-genetic links of the development of angiopathies in patients with type 2 diabetes mellitus and arterial hypertension. Sixteen-week nebivolol therapy caused a significant decrease in the level of gfycemia, blood pressure, and serum atherogenicity, and the rate of lipid peroxidation and an increase in basal vascular endothelial secretion of nitric oxide, resulting in diminished microalbuminuria.
About the Authors
A. S. AmetovRussian Medical Academy of Postgraduate Education
Russian Federation
T. Yu. Demidova
Russian Medical Academy of Postgraduate Education
Russian Federation
S. A. Kosykh
Russian Medical Academy of Postgraduate Education
Russian Federation
References
1. Дедов И.И., Шестакова М.В. Диабетическая нефропатия. - М., 2000.
2. Дедов И.И., Шестакова М.В. Сахарный диабет. - М., 2003.
3. Котов С.В., Калинин А.П., Рудакова И.Г. Диабетическая нейропатия. - М., 2000.
4. Малышев И.Ю., Манухина Е.Б. // Биохимия. - 1998. - Т.63, Вып.7. - С. 992-1006.
5. Celermajer D.S., Sorensen К.Е., Gooch V.М. // Lancet. - 1992. - Vol.340. - P. 1111-1115.
6. Guigliano D., Ceriello A., Paolisso G. // Diabetes Care. - 1996. - Vol.19. - P. 257-266.
7. Jensen Т., Stender S., Deckert T. // Diabetologia. - 1988. - Vol.31, Suppl.3. - P. 142-145.
8. Kapelrud H., Bangstad H.J., Dahl-Jorgensen K. // Br. Med. J. - 1991. - Vol.303. - P. 675-678.
9. Schmitz A. // Acta Diabetol. - 1992. - Vol.29. - P. 47-69.
10. Stehouwer C.D.A., Lambert J., Danker A.J.M., van Hinsbergh V.W.М. // Cardiovasc. Res. - 1997. - Vol.34. - P. 55-68.
11. Touyz. R.М. // Curr. Hypertens. Rep. - 2000. - Vol.2. - P. 98-105.
Review
For citations:
Ametov A.S., Demidova T.Yu., Kosykh S.A. Microalbuminuria in patients with type 2 diabetes mellitus and arterial hypertension: Possibilities of therapy. Problems of Endocrinology. 2005;51(4):2-6. (In Russ.) https://doi.org/10.14341/probl20055142-6
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