Dyslipidemia, increased lipolysis, and depleted heparin system in insulin resistance
https://doi.org/10.14341/probl200551518-21
Abstract
The purpose of this investigation was to make a comprehensive study of intravascular lipofysis, including extrahepatic lipoprotein lipase and hepatic triglyceride lipase in the serum, and the responsiveness of the heparin system in insulin resistance. Patients with arterial hypertension (n = 14), type 2 diabetes mellitus (n = 16), or metabolic syndrome (n = 10) were found to have higher serum lipolytic activity, triglyceridemia, lipidemia (in type 2 diabetes mellitus and metabolic syndrome) and hyperglycemia (in type 2 diabetes mellitus) than controls (10 healthy donors). Excessive blood intracellular reserve heparin secretion-induced release of extrahepatic lipoprotein lipase and hepatic triglyceride lipase into the vascular bed as a prerequisite for increasing the baseline level of lipolytic activity in insulin resistance pathology is discussed. The effects ofheparin (50 U/ml of serum) and insulin (2 U/ml of serum) on total lipoprotein lipase activity were not revealed in vitro. It is suggested that enhanced extracellular lipofysis and depleted endogenous heparin system result in the body's insulin resistance
About the Authors
V. V. SokolicInstitute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
Ukraine
T. G. Pertseva
Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
Ukraine
G. Kh. Bozhko
Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine
Ukraine
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Review
For citations:
Sokolic V.V., Pertseva T.G., Bozhko G.Kh. Dyslipidemia, increased lipolysis, and depleted heparin system in insulin resistance. Problems of Endocrinology. 2005;51(5):18-21. (In Russ.) https://doi.org/10.14341/probl200551518-21
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