Role of the renin-angiotensin system of the eye in the pathogenesis of diabetic retinopathy
https://doi.org/10.14341/probl200652147-49
Abstract
Numerous experimental and clinical studies indicate the involvement of the renin-angiotensin system in the development and progression of diabetic organ pathology. ASD is the main biochemical mechanism by which vasomotor and angiogenic reactions are realized. It interacts closely with its antagonist, the kallikrein-kinin system. Both systems are a cascade of proteolytic reactions leading to the formation of vasoactive peptides of angiotensin II and bradykinin. These endogenous regulators have the opposite effect on hemodynamics and water-salt balance.
About the Authors
M. Т. AznabayevUfa Research Institute of Eye Diseases, Academy of Sciences of the Republic of Bashkortostan
Russian Federation
U. R. Altynbayev
Ufa Research Institute of Eye Diseases, Academy of Sciences of the Republic of Bashkortostan
Russian Federation
I. N. Serezhin
Ufa Research Institute of Eye Diseases, Academy of Sciences of the Republic of Bashkortostan
Russian Federation
A. R. Shamratova
Ufa Research Institute of Eye Diseases, Academy of Sciences of the Republic of Bashkortostan
Russian Federation
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Review
For citations:
Aznabayev M.Т., Altynbayev U.R., Serezhin I.N., Shamratova A.R. Role of the renin-angiotensin system of the eye in the pathogenesis of diabetic retinopathy. Problems of Endocrinology. 2006;52(1):47-49. (In Russ.) https://doi.org/10.14341/probl200652147-49
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