Effect of chorionic gonadotropin on the activity of monocytes in relation to the phases of a menstrual cycle

Abstract

The effect of physiological doses of chorionic gonadotropin (CG) on monocytic oxidative and phagocytic activities was studied in females having different phases of a menstrual cycle. CG (100 IU/ml) was found to suppress the baseline monocytic production of active oxygen forms and to lower (10 and 100 IU/ml) the generation of myeloperoxidase irrespective the phase of the cycle. In the follicular phase of the cycle, CG (10 and 100 IU/ml) was shown to Inhibit monocytic phagocytic activity, but when given in a dose of 100 IU/ml, it concurrently enhanced the latex-induced production of active oxygen forms. In the lutein phase of the cycle, CG exerted opposite effects: it suppressed the parameters of latex-induced luminescence-dependent chemiluminescence and stimulated monocytic phagocytic activity, moreover, a significant inverse correlation between these parameters. Thus, the role of CG in the regulation of oxidative and phagocytic functions of peripheral monocytes infertile women depends on the phase of a menstrual cycle and the degree of monocytic activation