Postprandial lipemia and insulinemia in obese females with cholelithiasis

The authors studied the pattern of fatty tissue distribution in the body and revealed changes In the baseline and postprandial levels of serum lipids and insulin In females with cholelithiasis (CL) obese. Ninety-five females were examined. These included 41 patients with CL and obesity, 20 patients with the normal body mass index and CL, and 34 obese females without CL. The pattern of abdominal adipose tissue distribution was determined by computed tomography. The serum levels of major lipids and immunoreactive insulin (IRI) were measured at the baseline and 3 and 9 hours after administration of fat emulsion (130 g of fat per 2 m² of body surface). There was a significant predominance of the area of visceral adipose tissue (VFT) at the level of the gallbladder. In the groups of CL patients, the percent of VFT of the total abdominal adipose tissue was higher than that in obese patients without CL. During a dietary fat load test, a persistent postprandial hypertriglyceridemia and no increases in the levels of high-density lipoprotein cholesterol were observed in CL female patients irrespective of whether systemic obesity was present or absent. In the group of CL patients without signs of obesity, there were high baseline concentrations of IRI and no significant increase in IRI levels in response to the administration of fat emulsion

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