Pro- and antioxidative system in patients with hypothyroidism and its lipoic acid-induced changes

Abstract

The comparative studies revealed a considerable increase in free radical oxidation (FRO) processes in patients with compensated and decompensated hypothyroidism. In patients with decompensated hypothyroidism, the rate of FRO processes was 2.26 times higher than that in those with compensated hypothyroidism (p<0 05). In the patients with compensated hypothyroidism, there was a positive correlation between the fast plasma chemiluminescence flash (FPCF) and the plasma levels of triglycerides (r = +0.82) and low-density lipoproteins (r - +0.69) whereas in the patients with decompensated hypothyroidism, there was a positive correlation between FPCF and the plasma levels of cholesterol (r = +0.41). In vitro and ex vivo studies provided evidence suggesting the antioxidative properties of lipoic acid preparations (thioctacidum) diminishing FPCF by 46-70% in both groups of patients with hypothyroidism.