Study of gustatory sensitivity to phenylthiocarbamide in thyroid diseases
https://doi.org/10.14341/probl200955245-47
Abstract
The aim of the study was to reveal a relationship between gustatory sensitivity to phenylthiocarbamide (PTC) and thyroid disease. The distribution of PTC sensitivity was studied in 198 healthy individuals, 100 patients with autoimmune thyroiditis (AIT), 139 patients with nodular euthyroid goiter, and 100 patients operated on for thyroid cancer. There was a statistically significant decrease in the number of PTC-resistant male and females patients in the thyroid cancer group and an increase in the proportion of PTC-resistant male patients in the AIT and nodular euthyroid goiter groups.
About the Authors
A F MalenchenkoInstitute of Radiobiology of National Academy of Sciences of Belarus
Belarus
E S Makhlina
State Establishment State Establishment Republican Research Center of Radiation Medicine & Human Ecology
Belarus
V V Tatchikhin
Gomel regional clinical oncology outclinic of the Ministry of Health of Belarus
Belarus
I V Khlusova
Institute of Radiobiology of National Academy of Sciences of Belarus
Belarus
N D Lukovskaya
Institute of Radiobiology of National Academy of Sciences of Belarus
Russian Federation
References
1. Велданова М. В. Уроки тиреодологии: Пособие для врачей. - Петрозаводск, 2005.
2. Данилова Л. И. Болезни щитовидной железы и ассоциированные с ними заболевания. - Минск; Нагасаки, 2005.
3. Маленченко А. Ф. // Вопросы медицинской генетики и генетики человека. - Минск, 1971. - С. 84-88.
4. Маленченко А. Ф., Василенко И. Я., Василенко О. И. // Радиац. биол. Радиоэкол. - 2007. - Т. 47, № 4. - С. 435-443.
5. Фадеев В. В., Мельниченко Г. А. Гипотериоз: Руководство для врачей. - М., 2004.
6. Хмара И. М. Аутоиммунный тиреоидит в Республике Беларусь, 1989-1991 гг.: Автореф. дис. ... канд. мед. наук. - Минск, 1992.
7. Adler E., Hoon M. A., Mueller K. L. // Cell. - 2000. - Vol. 100. - P. 693-702.
8. Allison A. C., Blumberg B. S. // Hum. Biol. - 1959. - Vol. 31. - P. 352-359.
9. Astwood E. B. // J. Pharmacol. Exp. Ther. - 1943. - Vol. 78. - P. 79-89.
10. Azevedoi E., Krieqer H., Morton N. // Am. J. Hum. Genet - 1956. - Vol. 17. - P. 87-93.
11. Bartoshuk L. M., Duffy V. B., Miller J. G. // Physiol. Behav. - 1994. - Vol. 56. - P. 1165-1171.
12. Covarrurias E., Bazelatto G., Stevenson C. // Nature. - 1965. - Vol. 205. - P. 1036-1037.
13. Drewnovski A., Henderson A., Barrat-Fornelt A. // Drug. Metab. Disposit. - 2001. - Vol. 29, N 4. -P. 535-538.
14. Evans W. H., Kitchin F. D. Advans in Thyroid Research. - Oxford, 1961.
15. Expert Panel Report on the Consequences of the Chernobyl Accident // Rep. EUR 15248 EN. - Luxemburg, 1993.
16. Fox A. L. // Science. - 1931. - Vol. 73. - P. 14-15.
17. Harris H., Kalmus H. // Ann. Eugen. (Camb.). - 1949. - Vol. 14. - P. 24-31.
18. International Scientific Collaboration on the Consequences of the Chernobyl Accident // Final Report EUR 16538 EN. - Luxemburg, 1996.
19. Kalmus H., Trotter W. R. // Ann. Hum. Gen. Lond. - 1962. -Vol. 26. - P. 145-149,
20. McBurney D. H. // Handbook of Perception: Testing and Smalling / Eds E. C. Carterette, M. P. Friedman. - New York, 1978. - Vol. 6.
21. Olson G. M., Boehnke M., Nieswanager K. et al. // Genet. Epidemiol. - 1989. - Vol. 6. - P. 423-434.
22. The Thyroid: A Fundamental and Clinical Test / Eds S. C. Werner, S. H. Ingbar. - 4-th Ed. - New York, 1978.
Review
For citations:
Malenchenko A.F., Makhlina E.S., Tatchikhin V.V., Khlusova I.V., Lukovskaya N.D. Study of gustatory sensitivity to phenylthiocarbamide in thyroid diseases. Problems of Endocrinology. 2009;55(2):45-47. (In Russ.) https://doi.org/10.14341/probl200955245-47
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