Vaccination against pneumococcal and influenza infections in children and adolescents with type 1 diabetes

The effect of a Pneumo 23 vaccine against pneumococcal infection (n = 72; Subgroup 1) in combination with a Grippol vaccine against influenza infection (n = 28; Subgroup 2) was studied in children and adolescents with type 1 diabetes on insulin therapy. A control group consisted of 30 unvaccinated children. Unlike monovaccination, combined vaccination was ascertained to cause a significant reduction in the glycated hemoglobin following a year. The daily dose of insulin and the levels of high-density lipoprotein cholesterol, triglycerides, and b-lipoproteins were unchanged in all the groups. The level of albumins increased, by approximating to the normal values. The blood content of urea and creatinine remained to be in the normal range at all stages of the study. In Subgroup 2 children microalbuminuria was significantly decreased. Within a year after vaccination, all the children and adolescents with T1D also showed a reduction in the number of disease decompensation episodes, which being significant in Subgroup 2, resulting from the reductions in the incidence and severity of acute respiratory infections. In the vaccinated children, the number of late vascular diabetic complications remained unchanged. Vaccination against pneumococcal infection in 13 children before hospital discharge in the subcompensation phase was followed by the same changes in the biochemical parameters and the clinical course of T1D parameters as in the patients vaccinated in the phase of compensation of the disease. The dynamic abdominal ultrasonographic pattern was found to become worse in the unvaccinated patients than that in Subgroup 1 patients. Analysis of clinical, laboratory, and instrumental results indicated the stability of the course of T1D in the children and adolescents vaccinated against pneumococcal and influenza infections.

1. Вильниц А. А. и др. // Инфекционные заболевания у детей: проблемы, поиски, решения: Материалы Всероссийской науч.-практ. конф. (Санкт-Петербург, 18-20 мая 2004 г.). - СПб., 2004. - С. 36.

2. Дворецкий Л. И., Данилина В. А. // Инфекции и антимикроб. тер. - 2004. - Т. 6, № 4. - С. 126-133.

3. Костинов М. П., Смирнов В. В. // Лечащий врач. - 2000. - № 5-6. - С. 60-62.

4. Митюшин И. Л., Таточенко В. К. // Дет. доктор. - 2001. - № 2. - С. 46-51.

5. Immunization and the Prevention of Influenza and Pneumococcal Disease in People with Diabetes / by the American Diabetes Association, Inc, 2003. - Vol. 26. - P. 126-128.

6. Kukreja Anjli, Maclaren N. K. // J. Clin. Enocrinol. Metab. - 1999. - Vol. 84, N 12. - P. 4371-4378.