Lipid peroxidation and the state of the antioxidant defense system in patients with insulin-dependent diabetes mellitus

Abstract

Lipid peroxidation and status of the antioxidant defense were followed up in 24 patients with insulin-dependent diabetes over the course of treatment. Serum malonic dialdehyde was reliably (2.7 times) increased during the decompensation stage. Accumulation of conjugated dienes was not seen in all the patients; it depended on the content of free fatty acids. Their level decreased 1.1-1.3 times with depletion of the oxidation substrate. Variously directed changes of catalase activity were observed during the decompensation stage in the presence of a reliable (1.6 times) depression of ceruloplasmin, this reflecting various stages of adaptation of the antioxidant defense system. The level of malonic di aldehyde decreased after normalization of carbohydrate metabolism, but failed to reach the control values; a trend to recovery of the antioxidant composition was observed. The findings indicate disorders in the relationships between lipid peroxidation and antioxidant defense. Approaches to development of individual treatments and methods of correction are discussed.