Experience with the use of enalapril in children and adolescents with diabetic nephropathy and a normative level of blood pressure
https://doi.org/10.14341/probl199743519-22
Abstract
In order to study the efficacy of APP inhibitors in the treatment of diabetic nephropathy, 42 patients (13 men and 29 women) aged 11.6 to 20.9 years with diabetic nephropathy and normal arterial pressure were administered enalapril (“Renitek”) in a daily dose of 5 to 10 mg for 3 to 9 months. The treatment efficacy was assessed from the time course of albuminunuria and proteinuria, level of glycated hemoglobin HbAl, and arterial pressure values. Out of 35 patients with microalbuminuria treated for 3 to 9 months, albuminuria decreased in 32 (91.1%), and in 28 of these (80%) normalized. Out of 7 patients with proteinuria it notably decreased in 6, and in one patient albuminuria normalized. The results persisted for 9 months in the majority of cases after the drug was discontinued. Arterial pressure did not change much. Hence, enalapril is an effective drug for the treatment of diabetic nephropathy with microalbuminuria and proteinuria in normotensive patients.
About the Authors
G. I. SivousRussian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
E. P. Kasatkina
Russian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
V. N. Sokolovskaya
Russian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
E. A. Voychik
Russian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
T. M. Alekseeva
Russian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
L. P. Pashintseva
Russian Medical Academy of Postgraduate Education; Central Clinical Hospital No. 3; City Endocrinology Dispensary
Russian Federation
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Review
For citations:
Sivous G.I., Kasatkina E.P., Sokolovskaya V.N., Voychik E.A., Alekseeva T.M., Pashintseva L.P. Experience with the use of enalapril in children and adolescents with diabetic nephropathy and a normative level of blood pressure. Problems of Endocrinology. 1997;43(5):19-22. (In Russ.) https://doi.org/10.14341/probl199743519-22
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