Steroid hormone and noradrenalin effects on somatotropic hormone secretion by primary cultures of hypophyseocytes of rats of different ages
https://doi.org/10.14341/probl11298
Abstract
Dexamethasone and aldosterone in concentrations 10-8 to 10-6 stimulated STH secretion by hypophyseal cells of neonatal and adult rats under conditions of prolonged (72 h) incubation of primary cultures. Corticosterone and progesterone had a stimulating effect on STH release by hypophyseal cells. Long exposure of cultured suckling rat cells to dexamethasone resulted in increase of STH basal secretion and enhanced the stimulating effect of low concentration (10-7 mole) of noradrenalin on STH release during a subsequent shdrt (2 h) incubation. The results permit us to suggest that development of hypophyseal somatotropic function observed in the postnatal period may be to a certain measure explained by combined effects of corticosteroids and catecholamines.
About the Authors
V L GudoshnikovEndocrinology Research Centre
Russian Federation
T V Mamaeva
Endocrinology Research Centre
Russian Federation
V P Fedotov
Endocrinology Research Centre
Russian Federation
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Review
For citations:
Gudoshnikov V.L., Mamaeva T.V., Fedotov V.P. Steroid hormone and noradrenalin effects on somatotropic hormone secretion by primary cultures of hypophyseocytes of rats of different ages. Problems of Endocrinology. 1994;40(1):39-41. (In Russ.) https://doi.org/10.14341/probl11298
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