Effects of low dehydroepiandrosterone doses on the development of the gonadal hormonal function of young monkeys
https://doi.org/10.14341/probl11345
Abstract
The effect of prolonged administration of dehydroepiandrosterone (DHEA) to young male Papyo hamadryas on the subsequent course of sexual maturation was studied. Blood levels of testosterone, hydrocortisone, corticosterone, and 11-deoxyhydrocortisone were radioimmunoassayed over the course. of DHEA administration and after it. No appreciable changes in the said steroid compounds were observed during DHEA administration and soon after it. One year after DHEA administration, when the animals were in the pubertal stage, they had higher testosterone levels in the blood and a statistically higher mass in comparison with age-matched control monkeys. The most marked differences in testosterone levels were observed 2 years after DHEA administration, when the animals grew adult. Their testosterone levels surpassed the normal value by 4.7 times. The authors consider the effect of physiologic doses of DHEA the gonadal hormonal function from the “neurosteroid" concept viewpoint.
About the Authors
N. P. GoncharovEndocrinology research center of RAMS; Primatological center
Russian Federation
V. Yu. Butnev
Endocrinology research center of RAMS; Primatological center
Russian Federation
References
1. Albright F, Smith Р. Н., Fraser R. // Amer J. med. Sei. — 1942.— Vol. 204. — P. 625—648.
2. Albright F. // Ann. intern. Med. — 1947. — Vol. 27. — I1. 861—882.
3. Baulien E. E.. Robel I., Vatier O. et al. // Receptor—Receptor Interactions: Proceedings of the International Wenner—Gren Symposium / Eds K. Fuxe, L. F. Agnati. — Stockholm, 1987. — P. 89—104.
4. Boyar R. M., Finkelstein J. W., David R. et al. // New Engl. J. Med. — 1973. — Vol. 289. — P. 282—286.
5. Cohen H. N., Wallase A. M., Beastal G. H. et al. // Lancet. — 1981. — Vol. 1. — P. 689—692.
6. Copeland A. C., Paunier L., Sizonenko P. С. // J. Pediat. — 1977. — Vol. 91. — P. 985—990.
7. Counts D. R., Pescovitz О. H., Barnes К. M. et al. // J. clin. Endocr. — 1987. — Vol. 64. — P. 1174—1176.
8. Cutler G. B., Schiebinger R. J., Albertson B. D. et al. // Control of the Onset of Puberty / Eds M. G. Gnimbach et al. — London. 1990. — P. 507—533.
9. Ducharme J. R., Forest M. G. et al. // J. elm. Endocr. — 1976. — Vol.. N 3. — P. 468—476.
10. Forest M. G., Saez J. M., Bertrand J. // Some Aspects of Hypothalamic Regulation of Endocrine Functions / Ed. P. Franchimont. — Stuttgart, 1975. — P. 339—366.
11. Grumbach M. M., Richards G. E., Conte F. A., Kaplan S. L. // The Endocrine Function of the Human Adrenal Cortex / Eds V. H. T. James et al. — London, 1978. — P. 583—612.
12. Knudsen J. E, Mahesh Virendra B. // Endocrinology. — 1975. — Vol. 97. N 2. — P. 458—468.
13. Kraulis J., Traikov H., Sharpe M. et al. // Ibid. — 1978. — Vol. 103. — P. 1822—1828.
14. de Peretti E., Forest M. G. // J. clin. Endocr. — 1976. — Vol. 43. — P. 982—991.
15. Silverman S. H., Migeon C., Rosenberg E., Wilkins L. // Pediatrics. — 1952. — Vol. 10. — P. 426—431. '
16. Sizonenko P. C. // Control of the Onset of Puberty III: Proceedings of the 3-d International Conference on the Control of the Onset of Puberty. — Amsterdam, 1989. — P. 375—385.
Review
For citations:
Goncharov N.P., Butnev V.Yu. Effects of low dehydroepiandrosterone doses on the development of the gonadal hormonal function of young monkeys. Problems of Endocrinology. 1995;41(1):30-32. (In Russ.) https://doi.org/10.14341/probl11345
Views:
487
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
