The left ventricular myocardium in children at early stages of diabetes mellitus: Functional and morphometric parameters

Abstract

Its morphometric parameters (myocardial mass according to the procedure described by R. Devereuxe, end-diastolic volume and their ratio). Sixteen healthy children of the same age formed the control group. A gradual redistribution of transmitral flow to­wards the atrial systolic phase was found in children with a more than 5-year history of diabetes, which seems to be associated im­paired L V myocardial relaxation due to myocardial metabolic changes and to the occurrence of specific microangiopathies. The found changes progressed with time and correlated with the ap­pearance ofperipheral distal neuropathy. Within the first year of diabetes, there was a transient reduction in LV contractility, which appears to be associated with myocardial metabolic im­balance during the decompensation of the disease. There is a trend to LV myocardial hypertrophy 10years after the onset of the disease.