Role of GABA-A and GABA-B receptors of the brain in the hypothalamo-pituitary-testicular regulation by the negative feedback mechanism
https://doi.org/10.14341/probl11462
Abstract
The role of gamma-aminobutyric acid (GABA) of the brain and its receptors in the hypothalamo-pituitary-testicular (HPT) regulation by the negative feedback mechanism was for the first time studied in sham-operated and unilaterally castrated adult Wister rats. Increased level of GABA in the central nervous system following an injection of GABA transaminase inhibitor, aminoacetic acid, into the lateral ventricle of the brain was associated with activation of a compensatory increase of testosterone level in the blood, caused by unilateral castration. GABA effect is mediated through the receptors. Muscimol stimulation of GABA-A receptors of the central nervous system activated and their blocking with bicucullin inhibited a compensatory increase of testosterone level in the blood caused by hemicastration. Baclofen stimulation of cerebral GABA-B receptors was associated with an inhibition and their saclofen blocking with stimulation of the level of male sex steroid hormone in the blood following unilateral castration. A conclusion is made about participation of GABAergic mechanisms of the brain in the regulation of HPT function via the negative feedback mechanism
About the Authors
Ye. V. V. NaumenkoInstitute of Cytology and genetics, Siberian department of RAS
Russian Federation
A. V. Amikishiyeva
Institute of Cytology and genetics, Siberian department of RAS
Russian Federation
L. I. Serova
Institute of Cytology and genetics, Siberian department of RAS
Russian Federation
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Review
For citations:
V. Naumenko Ye.V., Amikishiyeva A.V., Serova L.I. Role of GABA-A and GABA-B receptors of the brain in the hypothalamo-pituitary-testicular regulation by the negative feedback mechanism. Problems of Endocrinology. 1995;41(4):36-38. (In Russ.) https://doi.org/10.14341/probl11462
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